| |
OR for IFNα positivity at day 1a
|
95% CI
|
OR for IFNα positivity at week 24a
|
95% CI
|
|---|
|
RF+ACPA+b
|
8.92
|
4.21–22.04
|
5.24
|
2.02–17.95
|
|
Current smokerb
|
1.70
|
0.91–3.15
|
2.18
|
1.01–4.56
|
|
CDAI day 1c
|
1.02
|
1.00–1.04
|
1.03
|
1.00–1.06
|
|
CRP day 1d
|
1.00
|
0.99–1.01
|
1.00
|
0.98–1.01
|
- Multivariable logistic regression with IFNα positivity at day 1 and week 24 as the dependent variable. At day 1, IFNα-positive (n = 91) and IFNα-negative (n = 255). At week 24, IFNα-positive (n = 41) and IFNα-negative (n = 305)
- RF rheumatoid factor, ACPA anti-citrullinated protein antibodies, CDAI clinical disease activity index
- aIFNα positivity defined as IFNα protein level above 136 fg/mL
- bYes versus no
- cPer point increase
- dPer 1 mg/L increase
