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Table 3 Factors associated with IFNα positivity at day 1 and week 24

From: Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trial

  OR for IFNα positivity at day 1a 95% CI OR for IFNα positivity at week 24a 95% CI
RF+ACPA+b 8.92 4.21–22.04 5.24 2.02–17.95
Current smokerb 1.70 0.91–3.15 2.18 1.01–4.56
CDAI day 1c 1.02 1.00–1.04 1.03 1.00–1.06
CRP day 1d 1.00 0.99–1.01 1.00 0.98–1.01
  1. Multivariable logistic regression with IFNα positivity at day 1 and week 24 as the dependent variable. At day 1, IFNα-positive (n = 91) and IFNα-negative (n = 255). At week 24, IFNα-positive (n = 41) and IFNα-negative (n = 305)
  2. RF rheumatoid factor, ACPA anti-citrullinated protein antibodies, CDAI clinical disease activity index
  3. aIFNα positivity defined as IFNα protein level above 136 fg/mL
  4. bYes versus no
  5. cPer point increase
  6. dPer 1 mg/L increase