Fig. 2

Reduced dimensions of longitudinal hematological data. A Medians of the reduced dimensions of the longitudinal hematological data of all 52 clinically classified D2T and 100 clinically classified non-D2T RA patients. B Medians of the reduced dimensions of the longitudinal hematological data of all 1873 RA patients in the UPOD-database, where a higher Y-score indicates a higher estimated probability of having D2T RA according to the classifications in structured and unstructured data, and the clinical classification (if available). All available hematological parameters were reduced to two dimensions (d1 and d2). For each patient, the median of these reduced dimensions over time is visualized. d, reduced dimension; D2T, difficult-to-treat; RA, rheumatoid arthritis; UPOD, Utrecht Patient Oriented Database