Skip to main content

Table 2 Comparison of baseline and 12 months characteristics between the low GC group and high GC group Results are presented as the mean ± SD

From: Influence of glucocorticoid treatment on trabecular bone score and bone remodeling regulators in early rheumatoid arthritis

 

Baseline

6 months

12 months

p value

 

lGC (22)

hGC (25)

lGC (22)

hGC (25)

lGC (22)

hGC (25)

 

Sex, female, n (%)

16 (72.7)

22 (88)

     

Age (years)

37.3 ± 5.02

38.96 ± 7.7

     

DAS28

3.6 ± 0.65

3.68 ± 0.77

  

2.85 ± 0.5**

3.02 ± 0.73*

*p < 0.05;**p < 0.05

Smokers, n (%)

5 (22.7)

6 (24)

  

4 (18.18)

6 (24)

 

Alcohol

11 (50)

14 (56)

–

–

–

5 (20)

 

ACPA, n (%)

20 (90.1)

24 (96)

–

–

–

–

 

RF, n (%)

19 (86.3)

23 (92)

–

–

–

–

 

Mean daily GC dose (mg)

–

–

  

4.27 ± 1.2

9.46 ± 1.62

 

Cumulative GC dose (mg)

–

–

  

1557.95 ± 442.15

3454 ± 445.73

 

BMI

23.27 ± 2.8

24.01 ± 2.6

  

23.05 ± 2.5

24.11 ± 2.45

 

BMD spine (g/cm2)

0.88 ± 0.09

0.87 ± 0.1

0.83 ± 0.2

0.87 ± 0.1

0.77 ± 0.07**

0.71 ± 0.08*

*p < 0.0001; *p < 0.0001

BMD femoral neck (g/cm2)

0.82 ± 0.11

0.77 ± 0.09

0.82 ± 0.11

0.76 ± 0.09

0.73 ± 0.10*

0.65 ± 0.08*

*p < 0.0001; *p < 0.0001

BMD total hip (g/cm2)

0.88 ± 0.11

0.83 ± 0.09

0.87 ± 0.11

0.82 ± 0.09

0.78 ± 0.09**

0.71 ± 0.08*

*p < 0.0001; *p < 0.0001

TBS

1.363 ± 0.48

1.315 ± 0.31

1.352 ± 0.31

1.306 ± 0.329

1.34 ± 0.49

1.185 ± 0.37** §

*p < 0.0001;§p < 0.0001

OPG (pg/ml)

448.7 ± 17.3

438.8 ± 16.2

432.6 ± 16.1

411.4 ± 15.1

400.7 ± 18.7**

358.1 ± 17.7* §

*p < 0.0001; *p < 0.0001

§p < 0.0001

RANKL (pg/ml)

275 ± 17.1

280.1 ± 16.1

301.3 ± 95.8

441 ± 89.9

401.4 ± 26.5**

417.7 ± 24.9*

*p < 0.05; ** p < 0.05

Scl (pg/ml)

288.4 ± 8.6

283 ± 8.1

296.9 ± 9.5

314.4 ± 8.9

344.6 ± 15**

384.6 ± 14* §

*p < 0.0001; *p < 0.0001

§p < 0.0001

Dkk (pg/ml)

3736.1 ± 166.4

3688.2 ± 156.1

3781.2 ± 147.2

3710.4 ± 138.1

3750 ± 142.3

3726.2 ± 133.4

0.773

  1. **12 months vs baseline in the low GC group; *12 months vs baseline in the high GC group; § high vs low GC