| Baseline | 6 months | 12 months | p value | |||
---|---|---|---|---|---|---|---|
 | lGC (22) | hGC (25) | lGC (22) | hGC (25) | lGC (22) | hGC (25) |  |
Sex, female, n (%) | 16 (72.7) | 22 (88) | Â | Â | Â | Â | Â |
Age (years) | 37.3 ± 5.02 | 38.96 ± 7.7 |  |  |  |  |  |
DAS28 | 3.6 ± 0.65 | 3.68 ± 0.77 |  |  | 2.85 ± 0.5** | 3.02 ± 0.73* | *p < 0.05;**p < 0.05 |
Smokers, n (%) | 5 (22.7) | 6 (24) | Â | Â | 4 (18.18) | 6 (24) | Â |
Alcohol | 11 (50) | 14 (56) | – | – | – | 5 (20) |  |
ACPA, n (%) | 20 (90.1) | 24 (96) | – | – | – | – |  |
RF, n (%) | 19 (86.3) | 23 (92) | – | – | – | – |  |
Mean daily GC dose (mg) | – | – |  |  | 4.27 ± 1.2 | 9.46 ± 1.62 |  |
Cumulative GC dose (mg) | – | – |  |  | 1557.95 ± 442.15 | 3454 ± 445.73 |  |
BMI | 23.27 ± 2.8 | 24.01 ± 2.6 |  |  | 23.05 ± 2.5 | 24.11 ± 2.45 |  |
BMD spine (g/cm2) | 0.88 ± 0.09 | 0.87 ± 0.1 | 0.83 ± 0.2 | 0.87 ± 0.1 | 0.77 ± 0.07** | 0.71 ± 0.08* | *p < 0.0001; *p < 0.0001 |
BMD femoral neck (g/cm2) | 0.82 ± 0.11 | 0.77 ± 0.09 | 0.82 ± 0.11 | 0.76 ± 0.09 | 0.73 ± 0.10* | 0.65 ± 0.08* | *p < 0.0001; *p < 0.0001 |
BMD total hip (g/cm2) | 0.88 ± 0.11 | 0.83 ± 0.09 | 0.87 ± 0.11 | 0.82 ± 0.09 | 0.78 ± 0.09** | 0.71 ± 0.08* | *p < 0.0001; *p < 0.0001 |
TBS | 1.363 ± 0.48 | 1.315 ± 0.31 | 1.352 ± 0.31 | 1.306 ± 0.329 | 1.34 ± 0.49 | 1.185 ± 0.37** § | *p < 0.0001;§p < 0.0001 |
OPG (pg/ml) | 448.7 ± 17.3 | 438.8 ± 16.2 | 432.6 ± 16.1 | 411.4 ± 15.1 | 400.7 ± 18.7** | 358.1 ± 17.7* § | *p < 0.0001; *p < 0.0001 §p < 0.0001 |
RANKL (pg/ml) | 275 ± 17.1 | 280.1 ± 16.1 | 301.3 ± 95.8 | 441 ± 89.9 | 401.4 ± 26.5** | 417.7 ± 24.9* | *p < 0.05; ** p < 0.05 |
Scl (pg/ml) | 288.4 ± 8.6 | 283 ± 8.1 | 296.9 ± 9.5 | 314.4 ± 8.9 | 344.6 ± 15** | 384.6 ± 14* § | *p < 0.0001; *p < 0.0001 §p < 0.0001 |
Dkk (pg/ml) | 3736.1 ± 166.4 | 3688.2 ± 156.1 | 3781.2 ± 147.2 | 3710.4 ± 138.1 | 3750 ± 142.3 | 3726.2 ± 133.4 | 0.773 |