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Table 1 Main demographic, biochemical, and genetic characteristics of patients

From: Circulating microRNA alternations in primary hyperuricemia and gout

  Normouricemic subjects (n = 130) Hyperuricemic patients (n = 45) Gout patients (n = 131) Fisher test p-value
n % n % n %  
Sex M/F 53/77 40.8/59.2 33/12 73.3/26.7 118/13 90.1/9.9 < 0.0001
Familial occurrence    17 41.5 50 38.5 0.8546
No treatment 130 100 21 46.7 18 13.7 < 0.0001
Allopurinol No treatment 24 53.3 98 74.8 < 0.0001
Febuxostat 0 0 15 11.5 < 0.0001
p.Q141K, GG 102 87.2 25 58.1 73 56.6 < 0.0001
GT 14 12.0 13 30.2 49 38.0 < 0.0001
TT 1 0.9 5 11.6 7 5.4 < 0.0001
no genetic data 13 10.0 2 4.4 2 1.5 < 0.0001
p.Q141K, MAF 16 6.8 23 26.7 63 24.4 < 0.0001
  Median (IQR) Range Median (IQR) Range Median (IQR) Range KW test p-value
Age of onset Not applicable 34 (40.5) 6–76 41.0 (23.0) 12–84 0.197
Age at the time of taking samples 41 (25.0) 18–76 48.0 (49.0) 11–78 53.0 (20.5) 14–90 < 0.0001
BMI 25.3 (4.8) 17.9–38.5 28.7 (6.1) 17.7–41 28.6 (5.4) 20.6–50 < 0.0001
SUA off treatment, μmol/L 337.0 (118.8) 140–617 450.5 (105.0) 253–601 462.0 (124.0) 245–683 < 0.0001
SUA on treatment, μmol/L Not applicable 424.0 (143.0) 250–608 378.0 (124.0) 167–725 0.2325
FE-UA Not collected 3.9 (2.0) 1.8–20 3.6 (1.5) 0.8–14.3 0.1716
eGFR-MDRD, mL/min/1.73 m2 Not collected 88.0 (35.6) 27.6–165 86.0 (21.5) 27.5–151 0.5505
Serum creatinine, μmol/L 75.5 (21.8) 49–121 79.0 (19.0) 47–132 81.0 (16.5) 48–189 0.0075
Max CRP 1.3 (1.8) 0.1–17.9 1.9 (4.6) 0.2–45.3 4.1 (7.2) 0.2–224.4 < 0.0001
  1. Reference range: SUA 120–416 μmol/L for men, 120–360 μmol/L for women; FE-UA 7.3 ± 1.3 for men, 10.3 ± 4.2 for women; eGFR-MDRD > 90 mL/min/1.73 m2 for healthy subjects (levels decline with age); serum creatinine 64–104 μmol/L for men, 49–90 μmol/L for women; CRP 0–5 mg/L
  2. GG—wild-type variant; GT—heterozygotic; TT—homozygotic; MAF minor frequency allele, IQR interquartile range, BMI body mass index, SUA serum uric acid, FE-UA fractional excretion of uric acid, eGFR-MDRD estimated glomerular filtration rate calculated using the Modification of Diet in Renal Disease, CRP C-reactive protein, KW test Kruskal-Wallis test