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Table 1 Main demographic, biochemical, and genetic characteristics of patients

From: Circulating microRNA alternations in primary hyperuricemia and gout

 

Normouricemic subjects (n = 130)

Hyperuricemic patients (n = 45)

Gout patients (n = 131)

Fisher test p-value

n

%

n

%

n

%

 

Sex M/F

53/77

40.8/59.2

33/12

73.3/26.7

118/13

90.1/9.9

< 0.0001

Familial occurrence

  

17

41.5

50

38.5

0.8546

No treatment

130

100

21

46.7

18

13.7

< 0.0001

Allopurinol

No treatment

24

53.3

98

74.8

< 0.0001

Febuxostat

0

0

15

11.5

< 0.0001

p.Q141K, GG

102

87.2

25

58.1

73

56.6

< 0.0001

GT

14

12.0

13

30.2

49

38.0

< 0.0001

TT

1

0.9

5

11.6

7

5.4

< 0.0001

no genetic data

13

10.0

2

4.4

2

1.5

< 0.0001

p.Q141K, MAF

16

6.8

23

26.7

63

24.4

< 0.0001

 

Median (IQR)

Range

Median (IQR)

Range

Median (IQR)

Range

KW test p-value

Age of onset

Not applicable

34 (40.5)

6–76

41.0 (23.0)

12–84

0.197

Age at the time of taking samples

41 (25.0)

18–76

48.0 (49.0)

11–78

53.0 (20.5)

14–90

< 0.0001

BMI

25.3 (4.8)

17.9–38.5

28.7 (6.1)

17.7–41

28.6 (5.4)

20.6–50

< 0.0001

SUA off treatment, μmol/L

337.0 (118.8)

140–617

450.5 (105.0)

253–601

462.0 (124.0)

245–683

< 0.0001

SUA on treatment, μmol/L

Not applicable

424.0 (143.0)

250–608

378.0 (124.0)

167–725

0.2325

FE-UA

Not collected

3.9 (2.0)

1.8–20

3.6 (1.5)

0.8–14.3

0.1716

eGFR-MDRD, mL/min/1.73 m2

Not collected

88.0 (35.6)

27.6–165

86.0 (21.5)

27.5–151

0.5505

Serum creatinine, μmol/L

75.5 (21.8)

49–121

79.0 (19.0)

47–132

81.0 (16.5)

48–189

0.0075

Max CRP

1.3 (1.8)

0.1–17.9

1.9 (4.6)

0.2–45.3

4.1 (7.2)

0.2–224.4

< 0.0001

  1. Reference range: SUA 120–416 μmol/L for men, 120–360 μmol/L for women; FE-UA 7.3 ± 1.3 for men, 10.3 ± 4.2 for women; eGFR-MDRD > 90 mL/min/1.73 m2 for healthy subjects (levels decline with age); serum creatinine 64–104 μmol/L for men, 49–90 μmol/L for women; CRP 0–5 mg/L
  2. GG—wild-type variant; GT—heterozygotic; TT—homozygotic; MAF minor frequency allele, IQR interquartile range, BMI body mass index, SUA serum uric acid, FE-UA fractional excretion of uric acid, eGFR-MDRD estimated glomerular filtration rate calculated using the Modification of Diet in Renal Disease, CRP C-reactive protein, KW test Kruskal-Wallis test