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Table 2 List of selected miRNAs

From: Circulating microRNA alternations in primary hyperuricemia and gout

Selected miRNA

Function related to hyperuricemia/gout

Reference

miR-17-5p*

suppresses NLRP3 inflammasome activation, miR-17-92 cluster

[17, 18]

miR-18a-5p*

increased by IL-1β in OA, miR-17-92 cluster

[19]

miR-30a-3p

regulates the autoimmune responses occurring in RA

[20]

miR-30c-5p*

inhibits pyroptosis incurred by NLRP3

[21]

miR-126-3p

targets the CCL2 mRNA

[22]

miR-133a-3p*

suppresses NLRP3 inflammasome activation

[23]

miR-142-3p*

inhibits the expression of ABCG2

[24]

miR-143-3p*

targets the GLUT9 mRNA

[25]

miR-146a-5p

increased by MSU crystals, regulates the inflammatory response

[26]

miR-155-5p

increased by MSU crystals, promotes the production of proinflammatory cytokines

[27]

miR-222-3p*

targets the ABCG2 mRNA

[28]

miR-223-3p

reduces NLRP3 inflammasome activity

[14]

miR-488-3p

regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA

[29]

miR-920

regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA

[29]

  1. OA osteoarthritis, RA rheumatoid arthritis, MSU monosodium urate, GA gouty arthritis
  2. miRNAs signed with a * indicate significant differences in TLDA screening