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Table 2 List of selected miRNAs

From: Circulating microRNA alternations in primary hyperuricemia and gout

Selected miRNA Function related to hyperuricemia/gout Reference
miR-17-5p* suppresses NLRP3 inflammasome activation, miR-17-92 cluster [17, 18]
miR-18a-5p* increased by IL-1β in OA, miR-17-92 cluster [19]
miR-30a-3p regulates the autoimmune responses occurring in RA [20]
miR-30c-5p* inhibits pyroptosis incurred by NLRP3 [21]
miR-126-3p targets the CCL2 mRNA [22]
miR-133a-3p* suppresses NLRP3 inflammasome activation [23]
miR-142-3p* inhibits the expression of ABCG2 [24]
miR-143-3p* targets the GLUT9 mRNA [25]
miR-146a-5p increased by MSU crystals, regulates the inflammatory response [26]
miR-155-5p increased by MSU crystals, promotes the production of proinflammatory cytokines [27]
miR-222-3p* targets the ABCG2 mRNA [28]
miR-223-3p reduces NLRP3 inflammasome activity [14]
miR-488-3p regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA [29]
miR-920 regulates the production of proinflammatory cytokines, targets the IL1B mRNA, decreased at patients with GA [29]
  1. OA osteoarthritis, RA rheumatoid arthritis, MSU monosodium urate, GA gouty arthritis
  2. miRNAs signed with a * indicate significant differences in TLDA screening