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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Fig. 1

Top rheumatoid arthritis skeletal muscle gene associations with inflammatory disease activity. a Bar chart categorizing top rheumatoid arthritis (RA) skeletal muscle differentially expressed genes highly associated (Spearman’s rho p < 0.001) with RA disease activity score in 28 joints (DAS-28) by PANTHER gene ontology (GO) biological processes (bars represent total number genes per category; percent gene process hits/total listed next to bars). b Bar chart showing Reactome pathways overrepresented (>2 genes per pathway) within top RA skeletal muscle genes highly associated (p < 0.001) with disease activity. c Bar chart categorizing top baseline RA skeletal muscle differentially expressed genes highly associated (Spearman’s rho p < 0.001) with improvement in RA disease activity following high-intensity interval training (HIIT) by PANTHER GO biological processes (bars represent total number genes per category; percent gene process hits/total listed next to bars). d Bar chart showing Reactome pathways overrepresented (>2 genes per pathway) within top baseline RA skeletal muscle genes highly associated (p < 0.001) with improvement in disease activity following HIIT. *Represents pathway that reached significance at the calculated false discovery rate (p < 0.05)

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