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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Fig. 2

Is altered skeletal muscle metabolism linked to fueling chronic inflammation? Figure summarizes skeletal muscle cellular metabolic pathways that may contribute to rheumatoid arthritis (RA) chronic inflammation based on differentially expressed RA muscle genes that are highly associated with disease activity score in 28 joints (DAS-28) (*) or improvements in DAS-28 following high-intensity interval training (HIIT) (#). Genes included in the pathways diagram are either highly associated (Spearman’s rho p < 0.001) or part of significantly associated ingenuity canonical pathways (p < 0.05). Genes whose expression significantly (p < 0.05) changes following HIIT are listed ($). Based on direction of positive (↑) or negative (↓) associations, genes whose function is to promote/upregulate (blue) or inhibit/downregulate (red) a specific pathway are highlighted. Bolded arrows represent proposed upregulated pathways. Dashed arrows represent proposed downregulated pathways. Green end-dotted arrows represent hypothesized pathways in which altered skeletal muscle metabolism may contribute to chronic immune-activation and inflammation in RA

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Arthritis Research & Therapy

ISSN: 1478-6362

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