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Table 2 Cross-sectional rheumatoid arthritis cohort #1: skeletal muscle canonical pathways associated with disease activity

From: Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Ingenuity canonical pathways – log
(p value)
Ratio (genes/total genes) Positively associated genes Negatively associated genes
DNA methylation and transcriptional repression signaling 2.18 7/33 CHD4,MTA2,SIN3A DNMT3A,DNMT3B,H4C14,MBD2
tRNA splicing 2.06 8/43 PDE1C,PDE4B,PDE5A,PDE8A MPPED2,PDE1A,PDE7A,SMPDL3B
Regulation of the epithelial mesenchymal transition in development pathway 1.96 12/82 AXIN1,GLI2,GLI3,JAG2,TCF4,WNT11,WNT8B, WNT9A RBPJ,SNAI2,WNT3A,WNT5B
Sphingosine and sphingosine-1-phosphate metabolism 1.84 3/8 ACER3 ASAH1,SGPP1
TCA cycle II (eukaryotic) 1.65 5/24 IDH3B,IDH3G DLD,MDH1B,SUCLA2
Branched-chain α-keto acid dehydrogenase complex*# 1.58 2/4 BCKDHB DLD
Molybdenum cofactor biosynthesis 1.58 2/4   MOCS3,NFS1
D-myo-inositol (1,4,5)-trisphosphate biosynthesis 1.57 5/25 PI4KA,PIP4K2A,PIP5K1B PI4K2A,PIP4K2B
Assembly of RNA polymerase I complex 1.44 3/11   POLR1B,TAF1A,TAF1C
  1. Results of ingenuity canonical pathways analyses, with pathways reaching significance at p > 0.05 included. Ratio refers to the number of differentially expressed skeletal muscle genes significantly associated (Spearman correlations, p < 0.05) with rheumatoid arthritis (RA) (n = 20 participants) disease activity score in 28 joints (DAS-28) compared to the total number genes in that pathway. Subsequent significant pathways with at least 50% gene overlap from previous listed pathways are filtered from this table. Please see Supplementary Table 2 for full list of significant Canonical Pathways.
  2. *#Pathway significantly associated in both the cross-sectional RA cohort #1 and changes with high-intensity interval training (HIIT) RA cohort #2 analyses