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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Altered circulating CCR6+and CXCR3+ T cell subsets are associated with poor renal prognosis in MPO-ANCA-associated vasculitis

Fig. 2

Decreased CCR6+ T cells and increased CXCR3+ T cells in active MPO-AAV patients. A PBMCs isolated from HC and active MPO-AAV patients were stained with PE-conjugated anti-CCR6, BV-421-conjugated anti-CCR4, and APC-conjugated anti-CXCR3 antibodies and then analyzed by flow cytometry (n MPO-AAV=33, n HC=20). The CD3+CD4+T cells were analyzed for surface expression of CCR4, CCR6, and CXCR3. Variation in percentages of CCR4+ and CXCR3+CD4+ T cells was observed between HC and active MPO-AAV patients. B Surface expression of CCR4, CCR6, and CXCR3 was also analyzed in CD3+CD8+ T cells. The percentages of CCR6+cells were decreased, and CXCR3+ cells were increased within the CD8+ T cell population in the peripheral blood of active MPO-AAV patients, when compared with HC

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