Fig. 4

The distribution of CD4+ effector memory T cell subsets in HC and active MPO-AAV patients. A Representative plots of CD4+ effector memory T cell subsets. Gating strategy for the identification of TEM1, TEM2, TEM17, and TEM17.1 according to the expression of chemokine receptors. The CD4+TEM cell subset (CD4+CCR7−CD45RO+) was gated for TEM1 cells (CD4+CD45RO+CCR7−CCR6−CXCR3+CCR4−), TEM2 cells (CD4+CD45RO+CCR7−CCR6−CXCR3−CCR4+), TEM17 cells (CD4+CD45RO+CCR7−CCR6+CXCR3−CCR4+), and TEM17.1 cell (CD4+CD45RO+CCR7−CCR6+CXCR3+CCR4−) subsets. B The summary data of the percentages of CD4+TEM cell subsets in the blood of patients with active MPO-AAV patients and HC (n MPO-AAV=33 HC=20). C Serum CCL20 level in active MPO-AAV patients and HC was evaluated by ELISA (n MPO-AAV=33 HC=20)