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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Urate-induced epigenetic modifications in myeloid cells

Fig. 4

ChIP-sequencing in urate-stimulated monocytes reveals no urate-dependent clustering based on phenotype for H3K4 trimethylation and H3K27 acetylation. Cluster and principal component analysis of datasets obtained on ChIP-sequencing for H3K4me3 (A, B) or H3K27ac (C, D) in 4 different donors (labeled D1-4) and 4 different conditions (medium, urate, medium+LPS, urate+LPS). Venn diagram of regions showing differential enrichment of either H3K27ac or H3K4me3 in urate primed cells (E) and list of overlapping genes based on histone marks at promoter regions, including log 2 fold change values for each of the two histone marks (F)

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