Fig. 1

The 5-class cubic LCMM for the whole cohort. A The figure shows smoothed curves for each of the 5 classes over time. The trajectories are smoothed using a generalised additive model. B The 5 panels show the “spaghetti plots” for each of the 5 classes where each line represents a single patient. SR slow responder, HDA high disease activity, NR non-responder, RR rapid responder, F flare