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Table 3 Multinomial logistic regression models of baseline variables associated with being in either the RR or SR latent class compared to NR using data from the whole cohort

From: Distinct patterns of disease activity over time in patients with active SLE revealed using latent class trajectory models

  Slow responder (SR) Rapid responder (RR)
  RRR 95% CI p RRR 95% CI p
Age group       
 <35 Ref Ref Ref Ref Ref Ref
 35–55 0.956 0.665, 1.373 0.806 1.092 0.799, 1.492 0.579
 >55 1.232 0.757, 2.001 0.401 0.137 0.868, 2.029 0.191
Female 1.071 0.518, 2.212 0.825 0.771 0.432, 1.137 0.378
Disease duration 0.988 0.969, 1.008 0.255 0.991 0.975, 1.008 0.312
Disease activity       
Baseline nBILAG-2004 score 1.092 1.061, 1.124 <0.001 1.083 1.055, 1.112 <0.001
 Baseline SLEDAI score 1.035 0.991, 1.080 0.122 1.023 0.985, 1.063 0.233
BILAG A or B constitutional 3.054 1.585, 5.889 0.001 4.047 2.257, 7.256 <0.001
BILAG A or B musculoskeletal 2.326 1.202, 4.503 0.012 3.129 1.733, 5.649 <0.001
BILAG A or B cardiorespiratory 1.710 0.959, 3.049 0.069 2.552 1.572, 4.145 <0.001
Medication       
 Study arm       
  Placebo Ref Ref Ref Ref Ref Ref
  E-mab 1200mg QoW 1.300 0.881, 1.920 0.187 1.394 1.003, 1.936 0.047
  E-mab 600mg QW 1.362 0.929, 1.997 0.113 1.244 0.895, 1.727 0.194
  Epratuzumab (either dose) 1.332 0.954, 1.859 0.092 1.317 0.993, 1.747 0.056
  Baseline steroid dose (mg/day) 1.022 1.003, 1.041 0.022 1.028 1.011, 1.045 0.001
Serology       
 Anti-Ro 0.853 0.619, 1.175 0.330 0.950 0.724. 0.124 0.708
 Anti-RNP 0.923 0.641, 1.329 0.668 1.316 0.977, 1.771 0.070
 Anti-dsDNA 0.992 0.691, 1.424 0.967 1.105 0.815, 1.497 0.518
 Anti-dsDNA titre* IU/ml
(n=314)
1.000 0.999, 1.002 0.776 1.000 1.000, 1.002 0.246
 Anti-Smith (Sm) 1.046 0.721, 1.519 0.810 1.184 0.867. 1.617 0.288
 Low C3 level 0.978 0.701, 1.389 0.941 1.029 0.770, 1.375 0.848
 C3 level (g/l) 0.806 0.493, 1.317 0.389 0.951 0.628, 1.441 0.814
 Low C4 level 0.803 0.578 1.116 0.192 1.015 0.770, 1.337 0.916
 C4 level (mg/l) 1.001 0.999, 1.002 0.438 1.001 0.999, 1.001 0.920
  1. *Only in patients with high anti-dsDNA