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Table 3 Multinomial logistic regression models of baseline variables associated with being in either the RR or SR latent class compared to NR using data from the whole cohort

From: Distinct patterns of disease activity over time in patients with active SLE revealed using latent class trajectory models

 

Slow responder (SR)

Rapid responder (RR)

 

RRR

95% CI

p

RRR

95% CI

p

Age group

      

 <35

Ref

Ref

Ref

Ref

Ref

Ref

 35–55

0.956

0.665, 1.373

0.806

1.092

0.799, 1.492

0.579

 >55

1.232

0.757, 2.001

0.401

0.137

0.868, 2.029

0.191

Female

1.071

0.518, 2.212

0.825

0.771

0.432, 1.137

0.378

Disease duration

0.988

0.969, 1.008

0.255

0.991

0.975, 1.008

0.312

Disease activity

      

 Baseline nBILAG-2004 score

1.092

1.061, 1.124

<0.001

1.083

1.055, 1.112

<0.001

 Baseline SLEDAI score

1.035

0.991, 1.080

0.122

1.023

0.985, 1.063

0.233

 BILAG A or B constitutional

3.054

1.585, 5.889

0.001

4.047

2.257, 7.256

<0.001

 BILAG A or B musculoskeletal

2.326

1.202, 4.503

0.012

3.129

1.733, 5.649

<0.001

 BILAG A or B cardiorespiratory

1.710

0.959, 3.049

0.069

2.552

1.572, 4.145

<0.001

Medication

      

 Study arm

      

  Placebo

Ref

Ref

Ref

Ref

Ref

Ref

  E-mab 1200mg QoW

1.300

0.881, 1.920

0.187

1.394

1.003, 1.936

0.047

  E-mab 600mg QW

1.362

0.929, 1.997

0.113

1.244

0.895, 1.727

0.194

  Epratuzumab (either dose)

1.332

0.954, 1.859

0.092

1.317

0.993, 1.747

0.056

  Baseline steroid dose (mg/day)

1.022

1.003, 1.041

0.022

1.028

1.011, 1.045

0.001

Serology

      

 Anti-Ro

0.853

0.619, 1.175

0.330

0.950

0.724. 0.124

0.708

 Anti-RNP

0.923

0.641, 1.329

0.668

1.316

0.977, 1.771

0.070

 Anti-dsDNA

0.992

0.691, 1.424

0.967

1.105

0.815, 1.497

0.518

 Anti-dsDNA titre* IU/ml

(n=314)

1.000

0.999, 1.002

0.776

1.000

1.000, 1.002

0.246

 Anti-Smith (Sm)

1.046

0.721, 1.519

0.810

1.184

0.867. 1.617

0.288

 Low C3 level

0.978

0.701, 1.389

0.941

1.029

0.770, 1.375

0.848

 C3 level (g/l)

0.806

0.493, 1.317

0.389

0.951

0.628, 1.441

0.814

 Low C4 level

0.803

0.578 1.116

0.192

1.015

0.770, 1.337

0.916

 C4 level (mg/l)

1.001

0.999, 1.002

0.438

1.001

0.999, 1.001

0.920

  1. *Only in patients with high anti-dsDNA