| Slow responder (SR) | Rapid responder (RR) | ||||
---|---|---|---|---|---|---|
 | RRR | 95% CI | p | RRR | 95% CI | p |
Age group | Â | Â | Â | Â | Â | Â |
 <35 | Ref | Ref | Ref | Ref | Ref | Ref |
 35–55 | 0.956 | 0.665, 1.373 | 0.806 | 1.092 | 0.799, 1.492 | 0.579 |
 >55 | 1.232 | 0.757, 2.001 | 0.401 | 0.137 | 0.868, 2.029 | 0.191 |
Female | 1.071 | 0.518, 2.212 | 0.825 | 0.771 | 0.432, 1.137 | 0.378 |
Disease duration | 0.988 | 0.969, 1.008 | 0.255 | 0.991 | 0.975, 1.008 | 0.312 |
Disease activity | Â | Â | Â | Â | Â | Â |
 Baseline nBILAG-2004 score | 1.092 | 1.061, 1.124 | <0.001 | 1.083 | 1.055, 1.112 | <0.001 |
 Baseline SLEDAI score | 1.035 | 0.991, 1.080 | 0.122 | 1.023 | 0.985, 1.063 | 0.233 |
 BILAG A or B constitutional | 3.054 | 1.585, 5.889 | 0.001 | 4.047 | 2.257, 7.256 | <0.001 |
 BILAG A or B musculoskeletal | 2.326 | 1.202, 4.503 | 0.012 | 3.129 | 1.733, 5.649 | <0.001 |
 BILAG A or B cardiorespiratory | 1.710 | 0.959, 3.049 | 0.069 | 2.552 | 1.572, 4.145 | <0.001 |
Medication | Â | Â | Â | Â | Â | Â |
 Study arm |  |  |  |  |  |  |
  Placebo | Ref | Ref | Ref | Ref | Ref | Ref |
  E-mab 1200mg QoW | 1.300 | 0.881, 1.920 | 0.187 | 1.394 | 1.003, 1.936 | 0.047 |
  E-mab 600mg QW | 1.362 | 0.929, 1.997 | 0.113 | 1.244 | 0.895, 1.727 | 0.194 |
  Epratuzumab (either dose) | 1.332 | 0.954, 1.859 | 0.092 | 1.317 | 0.993, 1.747 | 0.056 |
  Baseline steroid dose (mg/day) | 1.022 | 1.003, 1.041 | 0.022 | 1.028 | 1.011, 1.045 | 0.001 |
Serology | Â | Â | Â | Â | Â | Â |
 Anti-Ro | 0.853 | 0.619, 1.175 | 0.330 | 0.950 | 0.724. 0.124 | 0.708 |
 Anti-RNP | 0.923 | 0.641, 1.329 | 0.668 | 1.316 | 0.977, 1.771 | 0.070 |
 Anti-dsDNA | 0.992 | 0.691, 1.424 | 0.967 | 1.105 | 0.815, 1.497 | 0.518 |
 Anti-dsDNA titre* IU/ml (n=314) | 1.000 | 0.999, 1.002 | 0.776 | 1.000 | 1.000, 1.002 | 0.246 |
 Anti-Smith (Sm) | 1.046 | 0.721, 1.519 | 0.810 | 1.184 | 0.867. 1.617 | 0.288 |
 Low C3 level | 0.978 | 0.701, 1.389 | 0.941 | 1.029 | 0.770, 1.375 | 0.848 |
 C3 level (g/l) | 0.806 | 0.493, 1.317 | 0.389 | 0.951 | 0.628, 1.441 | 0.814 |
 Low C4 level | 0.803 | 0.578 1.116 | 0.192 | 1.015 | 0.770, 1.337 | 0.916 |
 C4 level (mg/l) | 1.001 | 0.999, 1.002 | 0.438 | 1.001 | 0.999, 1.001 | 0.920 |