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Table 1 Characteristics of cohort overall and stratified by seropositivity and elevated CRP (N = 870)a

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

  Overall Seropositive Elevated CRP
   No Yes P value No Yes P value
N 870 827 43   748 122  
Sex = female 666 (76.6) 632 (76.4) 34 (79.1) 0.83 564 (75.4) 102 (83.6) 0.062
Age (mean (SDb)) 51.78 (12.1) 51.57 (12.1) 55.67 (10.6) 0.03 51.72 (12.1) 52.12 (11.9) 0.741
BMIb category     0.727    < 0.001
 Underweight 14 ( 1.7) 14 ( 1.7) 0 ( 0.0)   13 ( 1.8) 1 ( 0.9)  
 Normal weight 374 (44.2) 357 (44.4) 17 (40.5)   349 (47.9) 25 (21.4)  
 Overweight 293 (34.6) 276 (34.3) 17 (40.5)   258 (35.4) 35 (29.9)  
 Obese 165 (19.5) 157 (19.5) 8 (19.0)   109 (15.0) 56 (47.9)  
Age left education     0.836    0.035
 Less than 16 years 51 ( 6.0) 49 ( 6.0) 2 ( 4.8)   43 ( 5.8) 8 ( 6.7)  
 16–17 years 333 (38.9) 319 (39.1) 14 (33.3)   278 (37.7) 55 (46.2)  
 18–20 years 209 (24.4) 198 (24.3) 11 (26.2)   176 (23.8) 33 (27.7)  
 21+ years 264 (30.8) 249 (30.6) 15 (35.7)   241 (32.7) 23 (19.3)  
Smoking status     0.729    0.08
 Never smoker 498 (57.3) 471 (57.0) 27 (62.8)   439 (58.8) 59 (48.4)  
 Former smoker 315 (36.2) 301 (36.4) 14 (32.6)   260 (34.8) 55 (45.1)  
 Current smoker 56 ( 6.4) 54 ( 6.5) 2 ( 4.7)   48 ( 6.4) 8 ( 6.6)  
Ethnicity     0.001    0.094
 White 851 (97.9) 811 (98.2) 40 (93.0)   734 (98.3) 117 (95.9)  
 Mixed 4 ( 0.5) 4 ( 0.5) 0 ( 0.0)   4 ( 0.5) 0 ( 0.0)  
 Asian 8 ( 0.9) 5 ( 0.6) 3 ( 7.0)   6 ( 0.8) 2 ( 1.6)  
 Black 4 ( 0.5) 4 ( 0.5) 0 ( 0.0)   2 ( 0.3) 2 ( 1.6)  
 Chinese 2 ( 0.2) 2 ( 0.2) 0 ( 0.0)   1 ( 0.1) 1 ( 0.8)  
Average units of alcohol per week (mean (SDb)) 7.44 (8.83) 7.40 (8.76) 8.21 (10.20) 0.559 7.53 (8.94) 6.90 (8.14) 0.472
Diabetes mellitus 28 ( 3.2) 23 ( 2.8) 5 (11.9) 0.005 20 ( 2.7) 8 ( 6.6) 0.048
Psoriasis 38 ( 4.4) 37 ( 4.5) 1 ( 2.4) 0.789 30 ( 4.0) 8 ( 6.6) 0.298
Hypertension 134 (15.5) 126 (15.3) 8 (18.6) 0.714 104 (14.0) 30 (24.8) 0.003
Depression 169 (19.7) 164 (20.1) 5 (11.6) 0.245 138 (18.6) 31 (26.3) 0.068
IMDb quintile     0.587    0.749
 1 (most deprived) 64 ( 7.9) 61 ( 7.9) 3 ( 7.5)   56 ( 8.0) 8 ( 6.8)  
 2 133 (16.3) 126 (16.3) 7 (17.5)   109 (15.6) 24 (20.5)  
 3 186 (22.8) 181 (23.4) 5 (12.5)   160 (22.9) 26 (22.2)  
 4 212 (26.0) 199 (25.7) 13 (32.5)   182 (26.1) 30 (25.6)  
 5 (least deprived) 220 (27.0) 208 (26.8) 12 (30.0)   191 (27.4) 29 (24.8)  
  1. aData are shown as number (percentage) unless otherwise indicated. bSD, standard deviation; BMI, body mass index; IMD, Index of Multiple Deprivation