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Table 2 Symptoms and pattern of joint pain, overall and stratified by seropositivity and elevated CRP

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

  Overall Seronegative Seropositive Difference in proportionsa, b (95% CI) Normal CRP Elevated CRP Difference in proportionsa (95% CI)
N 870 827 43   748 122  
Symptoms
 Joint pain 154 (17.9) 147 (18.0) 7 (16.3) − 1.76 (− 13.1 to 9.59) 128 (17.4) 26 (21.5) 4.12 (− 3.69 to 11.93)
 Joint swelling 53 ( 6.2) 52 ( 6.4) 1 ( 2.4)   44 ( 6.0) 9 ( 7.4) 1.48 (− 3.5 to 6.45)
 Joint stiffness 100 (11.7) 94 (11.5) 6 (14.3) 2.77 (− 8.04 to 13.57) 75 (10.2) 25 (20.7) 10.48 (2.95 to 18.02)
 Joint burning 32 ( 3.7) 31 ( 3.8) 1 ( 2.4)   24 ( 3.3) 8 ( 6.6) 3.35 (− 1.26 to 7.96)
 Joint tingling 27 ( 3.2) 27 ( 3.3) 0 ( 0.0)   22 ( 3.0) 5 ( 4.2) 1.18 (− 2.6 to 4.96)
 Colour change 15 ( 1.8) 15 ( 1.8) 0 ( 0.0)   11 ( 1.5) 4 ( 3.3) 1.81 (− 1.49 to 5.12)
 Cramp 94 (10.9) 84 (10.3) 10 (23.8) 13.53 (0.48 to 26.58) 80 (10.8) 14 (11.7) 0.84 (− 5.32 to 7.01)
 Weakness 77 ( 9.0) 71 ( 8.7) 6 (14.3) 5.57 (− 5.18 to 16.33) 62 ( 8.4) 15 (12.4) 3.97 (− 2.23 to 10.18)
 Fatigue 143 (16.7) 134 (16.4) 9 (21.4) 4.99 (− 7.68 to 17.65) 117 (15.9) 26 (21.5) 5.59 (− 2.19 to 13.37)
 Distress 138 (16.1) 132 (16.2) 6 (14.3) − 1.89 (− 12.77 to 8.99) 112 (15.2) 26 (21.7) 6.49 (− 1.32 to 14.3)
 Concentration difficulties 67 ( 7.8) 66 ( 8.1) 1 ( 2.4)   51 ( 6.9) 16 (13.2) 6.31 (0.01 to 12.62)
 Sleep disturbances 175 (20.3) 163 (19.9) 12 (28.6) 8.64 (− 5.29 to 22.58) 137 (18.5) 38 (31.4) 12.87 (4.13 to 21.6)
Pattern of joint pain        
 Symmetrical joint pain 149 (17.1) 137 (16.6) 12 (27.9) 11.34 (− 2.3 to 24.99) 116 (15.5) 33 (27.0) 11.54 (3.24 to 19.84)
 Small joint pain 198 (22.8) 183 (22.1) 15 (34.9) 12.76 (− 1.77 to 27.28) 159 (21.3) 39 (32.0) 10.71 (1.93 to 19.49)
 Large joint pain 270 (31.0) 256 (31.0) 14 (32.6) 1.6 (− 12.75 to 15.96) 222 (29.7) 48 (39.3) 9.67 (0.4 to 18.93)
  1. aDifference in proportions is considered significantly different from zero if the 95% CI does not include zero
  2. bDifference in proportions not able to be calculated if the number in one strata is less than 5 as the CI cannot be (reliably) calculated