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Table 2 Symptoms and pattern of joint pain, overall and stratified by seropositivity and elevated CRP

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

 

Overall

Seronegative

Seropositive

Difference in proportionsa, b (95% CI)

Normal CRP

Elevated CRP

Difference in proportionsa (95% CI)

N

870

827

43

 

748

122

 

Symptoms

 Joint pain

154 (17.9)

147 (18.0)

7 (16.3)

− 1.76 (− 13.1 to 9.59)

128 (17.4)

26 (21.5)

4.12 (− 3.69 to 11.93)

 Joint swelling

53 ( 6.2)

52 ( 6.4)

1 ( 2.4)

 

44 ( 6.0)

9 ( 7.4)

1.48 (− 3.5 to 6.45)

 Joint stiffness

100 (11.7)

94 (11.5)

6 (14.3)

2.77 (− 8.04 to 13.57)

75 (10.2)

25 (20.7)

10.48 (2.95 to 18.02)

 Joint burning

32 ( 3.7)

31 ( 3.8)

1 ( 2.4)

 

24 ( 3.3)

8 ( 6.6)

3.35 (− 1.26 to 7.96)

 Joint tingling

27 ( 3.2)

27 ( 3.3)

0 ( 0.0)

 

22 ( 3.0)

5 ( 4.2)

1.18 (− 2.6 to 4.96)

 Colour change

15 ( 1.8)

15 ( 1.8)

0 ( 0.0)

 

11 ( 1.5)

4 ( 3.3)

1.81 (− 1.49 to 5.12)

 Cramp

94 (10.9)

84 (10.3)

10 (23.8)

13.53 (0.48 to 26.58)

80 (10.8)

14 (11.7)

0.84 (− 5.32 to 7.01)

 Weakness

77 ( 9.0)

71 ( 8.7)

6 (14.3)

5.57 (− 5.18 to 16.33)

62 ( 8.4)

15 (12.4)

3.97 (− 2.23 to 10.18)

 Fatigue

143 (16.7)

134 (16.4)

9 (21.4)

4.99 (− 7.68 to 17.65)

117 (15.9)

26 (21.5)

5.59 (− 2.19 to 13.37)

 Distress

138 (16.1)

132 (16.2)

6 (14.3)

− 1.89 (− 12.77 to 8.99)

112 (15.2)

26 (21.7)

6.49 (− 1.32 to 14.3)

 Concentration difficulties

67 ( 7.8)

66 ( 8.1)

1 ( 2.4)

 

51 ( 6.9)

16 (13.2)

6.31 (0.01 to 12.62)

 Sleep disturbances

175 (20.3)

163 (19.9)

12 (28.6)

8.64 (− 5.29 to 22.58)

137 (18.5)

38 (31.4)

12.87 (4.13 to 21.6)

Pattern of joint pain

       

 Symmetrical joint pain

149 (17.1)

137 (16.6)

12 (27.9)

11.34 (− 2.3 to 24.99)

116 (15.5)

33 (27.0)

11.54 (3.24 to 19.84)

 Small joint pain

198 (22.8)

183 (22.1)

15 (34.9)

12.76 (− 1.77 to 27.28)

159 (21.3)

39 (32.0)

10.71 (1.93 to 19.49)

 Large joint pain

270 (31.0)

256 (31.0)

14 (32.6)

1.6 (− 12.75 to 15.96)

222 (29.7)

48 (39.3)

9.67 (0.4 to 18.93)

  1. aDifference in proportions is considered significantly different from zero if the 95% CI does not include zero
  2. bDifference in proportions not able to be calculated if the number in one strata is less than 5 as the CI cannot be (reliably) calculated
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Arthritis Research & Therapy

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