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Table 3 Characteristics and associations with symmetrical and small joint pain (N = 764)a

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

Characteristic

 

Number (%) without symmetrical and small joint pain, unless otherwise specified

Number (%) with small and symmetrical joint pain, unless otherwise specified

Univariate logistic regression odds ratio (95% CI)c

Multivariate logistic regression odds ratio (95% confidence interval)b

Age (continuous, mean (SDc))

50.9 (11.9)

57.4 (12.0)

1.05 (1.03, 1.06)

1.04 (1.02, 1.07)

Sex

Male

156 (87.2)

23 (12.9)

Reference

Reference

 

Female

514 (87.9)

71 (12.1)

0.94 (0.57, 1.55)

1.18 (0.67, 2.06)

Smoking status

Never smoker

401 (89.7)

46 (10.3)

Reference

Reference

 

Former smoker

235 (85.5)

40 (14.6)

1.48 (0.94, 2.33)

1.28 (0.78, 2.11)

 

Current smoker

34 (81.0)

8 (19.1)

2.05 (0.90, 4.70)

1.55 (0.61, 3.92)

Average units of alcohol consumed per week (continuous) (mean (SDc))

7.5 (8.8)

7.0 (8.9)

1.00 (0.97, 1.02)

0.99 (0.97, 1.02)

BMIc category

Underweight

13 (100)

0

Null

Null

 

Normal weight

309 (91.7)

28 (8.3)

Reference

Reference

 

Overweight

220 (84.0)

42 (16.0)

2.11 (1.27, 3.50)

1.57 (0.91, 2.71)

 

Obese

128 (84.2)

24 (15.8)

2.07 (1.16, 3.71)

1.63 (0.84, 3.17)

Educational age left education

Less than 16 years

35 (74.5)

12 (25.5)

1.79 (0.87, 3.71)

0.84 (0.37, 1.91)

 

16–17 years

246 (84.0)

47 (16.0)

Reference

Reference

 

18–20 years

176 (92.2)

15 (7.9)

0.45 (0.24, 0.82)

0.51 (0.27, 0.97)

 

21+ years

213 (91.4)

20 (8.6)

0.49 (0.28, 0.86)

0.63 (0.35, 1.14)

IMDc quintile

1

48 (80.0)

12 (20.0)

Reference

Reference

 

2

109 (89.3)

13 (10.7)

0.48 (0.20, 1.12)

0.51 (0.2, 1.31)

 

3

158 (89.8)

18 (10.2)

0.46 (0.21, 1.01)

0.47 (0.2, 1.13)

 

4

171 (86.4)

27 (13.6)

0.63 (0.30, 1.34)

0.65 (0.28, 1.53)

 

5

184 (88.5)

24 (11.5)

0.52 (0.24, 1.12)

0.51 (0.21, 1.22)

Depression

No

564 (90.4)

60 (9.6)

Reference

Reference

 

Yes

106 (75.7)

34 (24.3)

3.02 (1.89, 4.82)

2.77 (1.65, 4.65)

CRPc

Normal

587 (88.7)

75 (11.3)

Reference

Reference

 

Elevated

83 (81.4)

19 (20.2)

1.79 (1.03, 3.12)

1.19 (0.63, 2.25)

Antibody status

Seronegative

642 (88.3)

85 (11.7)

Reference

Reference

 

Seropositive

28 (75.7)

9 (24.3)

2.43 (1.11, 5.32)

2.55 (1.09, 5.97)

  1. aIncluded only complete cases. b Odds ratio is considered significantly different from one if the 95% CI does not include one. cSD, standard deviation; BMI, body mass index; IMD, Index of Multiple Deprivation, CRP: C-reactive protein
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Arthritis Research & Therapy

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