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Table 3 Characteristics and associations with symmetrical and small joint pain (N = 764)a

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

Characteristic   Number (%) without symmetrical and small joint pain, unless otherwise specified Number (%) with small and symmetrical joint pain, unless otherwise specified Univariate logistic regression odds ratio (95% CI)c Multivariate logistic regression odds ratio (95% confidence interval)b
Age (continuous, mean (SDc)) 50.9 (11.9) 57.4 (12.0) 1.05 (1.03, 1.06) 1.04 (1.02, 1.07)
Sex Male 156 (87.2) 23 (12.9) Reference Reference
  Female 514 (87.9) 71 (12.1) 0.94 (0.57, 1.55) 1.18 (0.67, 2.06)
Smoking status Never smoker 401 (89.7) 46 (10.3) Reference Reference
  Former smoker 235 (85.5) 40 (14.6) 1.48 (0.94, 2.33) 1.28 (0.78, 2.11)
  Current smoker 34 (81.0) 8 (19.1) 2.05 (0.90, 4.70) 1.55 (0.61, 3.92)
Average units of alcohol consumed per week (continuous) (mean (SDc)) 7.5 (8.8) 7.0 (8.9) 1.00 (0.97, 1.02) 0.99 (0.97, 1.02)
BMIc category Underweight 13 (100) 0 Null Null
  Normal weight 309 (91.7) 28 (8.3) Reference Reference
  Overweight 220 (84.0) 42 (16.0) 2.11 (1.27, 3.50) 1.57 (0.91, 2.71)
  Obese 128 (84.2) 24 (15.8) 2.07 (1.16, 3.71) 1.63 (0.84, 3.17)
Educational age left education Less than 16 years 35 (74.5) 12 (25.5) 1.79 (0.87, 3.71) 0.84 (0.37, 1.91)
  16–17 years 246 (84.0) 47 (16.0) Reference Reference
  18–20 years 176 (92.2) 15 (7.9) 0.45 (0.24, 0.82) 0.51 (0.27, 0.97)
  21+ years 213 (91.4) 20 (8.6) 0.49 (0.28, 0.86) 0.63 (0.35, 1.14)
IMDc quintile 1 48 (80.0) 12 (20.0) Reference Reference
  2 109 (89.3) 13 (10.7) 0.48 (0.20, 1.12) 0.51 (0.2, 1.31)
  3 158 (89.8) 18 (10.2) 0.46 (0.21, 1.01) 0.47 (0.2, 1.13)
  4 171 (86.4) 27 (13.6) 0.63 (0.30, 1.34) 0.65 (0.28, 1.53)
  5 184 (88.5) 24 (11.5) 0.52 (0.24, 1.12) 0.51 (0.21, 1.22)
Depression No 564 (90.4) 60 (9.6) Reference Reference
  Yes 106 (75.7) 34 (24.3) 3.02 (1.89, 4.82) 2.77 (1.65, 4.65)
CRPc Normal 587 (88.7) 75 (11.3) Reference Reference
  Elevated 83 (81.4) 19 (20.2) 1.79 (1.03, 3.12) 1.19 (0.63, 2.25)
Antibody status Seronegative 642 (88.3) 85 (11.7) Reference Reference
  Seropositive 28 (75.7) 9 (24.3) 2.43 (1.11, 5.32) 2.55 (1.09, 5.97)
  1. aIncluded only complete cases. b Odds ratio is considered significantly different from one if the 95% CI does not include one. cSD, standard deviation; BMI, body mass index; IMD, Index of Multiple Deprivation, CRP: C-reactive protein