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Table 4 Symptoms and associations with symmetrical and small joint pain (N = 829)

From: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the PRe-clinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort

Symptom present

Number without symmetrical and small joint pain (%)

Number with small and symmetrical joint pain (%)

Univariate logistic regression odds ratio (95% CI)$

Multivariatea logistic regression odds ratio (95% confidence interval)b

Joint pain

51 (7.5)

53 (36.8)

7.2 (4.7, 11.3)

2.16 (1.15, 4.09)

Joint swell

84 (10.8)

20 (41.7)

5.9 (3.2, 11.0)

1.03 (0.40, 2.64)

Joint stiff

59 (8.0)

45 (48.4)

10.8 (6.6, 17.5)

3.00 (1.50, 6.00)

Joint burn

88 (11.0)

16 (57.1)

10.8 (4.9, 23.6)

2.91 (1.03, 8.24)

Joint tingling

85 (10.6)

19 (73.1)

22.9 (9.4, 56.1)

7.32 (2.49, 21.49)

Colour

100 (12.3)

4 (28.6)

2.9 (0.9, 9.3)

0.52 (0.10, 2.84)

Cramp

78 (10.6)

26 (28.9)

3.4 (2.1, 5.7)

1.47 (0.75, 2.88)

Weakness

73 (9.7)

31 (42.5)

6.9 (4.1, 11.7)

1.28 (0.61, 2.70)

Fatigue

56 (8.1)

48 (34.5)

6.0 (3.8, 9.3)

2.03 (1.06, 3.89)

Distress

69 (9.9)

35 (6.5)

3.3 (2.1, 5.2)

0.89 (0.44, 1.79)

Concentration difficulties

80 (10.4)

24 (39.3)

5.6 (3.2, 9.8)

0.88 (0.36, 2.15)

Sleep disturbances

58 (8.8)

46 (27.2)

3.9 (2.5, 6.0)

1.31 (0.71, 2.42)

  1. aAll symptoms modelled together, with no other adjustment. b Odds ratio is considered significantly different from one if the 95% CI does not include one