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1
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TBT changes constitute one of the integral features of OA initiation and progression
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2
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TBT phenotype of patients with progressive OA is associated with apparent thickening of horizontal trabeculae and thinning of vertical trabeculae
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3
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TBT parameters evaluated from 2D radiographs reflect the subchondral trabecular bone 3D microarchitecture assessed by CT
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4
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Using TBT parameters in OA trials does not require supplementary methods for cross-calibration of devices at different clinical centers in addition to the standardized radiographic data acquisition procedures already performed in phase III trials
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