N° | What is already known |
---|---|
1 | TBT changes constitute one of the integral features of OA initiation and progression |
2 | TBT phenotype of patients with progressive OA is associated with apparent thickening of horizontal trabeculae and thinning of vertical trabeculae |
3 | TBT parameters evaluated from 2D radiographs reflect the subchondral trabecular bone 3D microarchitecture assessed by CT |
4 | Using TBT parameters in OA trials does not require supplementary methods for cross-calibration of devices at different clinical centers in addition to the standardized radiographic data acquisition procedures already performed in phase III trials |