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Table 5 Best TBT descriptors from selected studies, for different OA-related tasks

From: Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint

  Population Major findings Best descriptor
Messent et al. (2005) [26] 110 FSA of vertical FSA was greater in OA subjects than non-OA subjects, consistent with increased vertical trabecular number associated with thinning and fenestration of coarser trabeculae Increase in vertical FD
Messent et al. (2005) [12] 40 No link was found between the degree of subchondral trabecular bone changes, analyzed by fractal signature analysis (FSA), and the rate of cartilage destruction, quantified by the annual rate of joint space narrowing (JSN) Decrease in vertical FD and horizontal FD
Wolski et al. 2011 [38] 48 Significant differences in TBT, measured by that the variance orientation transform (VOT) method, between subjects with and without cartilage defects, suggesting thinning and fenestration of trabecular bone in knees with cartilage defects Increase in vertical FD and horizontal FD
Janvier et al. (2017) [11] 1124 Baseline TBTA of the tibial plateau at baseline was predictive of medial knee JSN progression. The best model included clinical covariates, JSN and TBTA, measured by Whittle estimator (Whe) (AUC = 0.75) Increase in vertical FD