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Table 1 Top 20 genes with the highest absolute FC in 65% mechanically stressed cartilage compared to controls

From: Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Ensemble ID Gene name FC FDRa Differential expression in OA cartilage [5]b
ENSG00000115461 IGFBP5 6.01 7.81 × 10−3  
ENSG00000137745 MMP13 5.19 4.84 × 10−2  
ENSG00000204103 MAFB 2.97 4.66 × 10−3
ENSG00000148344 PTGES 2.92 8.29 × 10−3
ENSG00000041982 TNC 2.80 8.51 × 10−3
ENSG00000141753 IGFBP4 2.59 3.50 × 10−2
ENSG00000160111 CPAMD8 0.39 4.98 × 10−2
ENSG00000166165 CKB 0.38 1.04 × 10−2
ENSG00000106258 CYP3A5 0.38 3.62 × 10−2  
ENSG00000107736 CDH23 0.37 6.88 × 10−3  
ENSG00000187720 THSD4 0.35 1.44 × 10−2  
ENSG00000144908 ALDH1L1 0.33 2.22 × 10−3
ENSG00000092758 COL9A3 0.32 4.89 × 10−2  
ENSG00000162998 FRZB 0.32 8.51 × 10−3
ENSG00000170891 CYTL1 0.32 4.11 × 10−2  
ENSG00000064205 WISP2 0.31 1.08 × 10−3
ENSG00000082196 C1QTNF3 0.30 3.64 × 10−2
ENSG00000122756 CNTFR 0.27 1.44 × 10−2
ENSG00000165966 PDZRN4 0.26 1.44 × 10−2
ENSG00000167779 IGFBP6 0.19 3.07 × 10−4  
  1. aTo correct for multiple testing, the Benjamini-Hochberg method was applied to P-values and reported as the false discovery rate (FDR). bGene expression changes measured in RNA-sequencing data between preserved and lesioned OA articular cartilage, with preserved as reference [5]. Legend: FC fold change, FDR false discovery rate