|
Ensemble ID
|
Gene name
|
FC
|
FDRa
|
Differential expression in OA cartilage [5]b
|
|---|
|
ENSG00000115461
|
IGFBP5
|
6.01
|
7.81 × 10−3
| |
|
ENSG00000137745
|
MMP13
|
5.19
|
4.84 × 10−2
| |
|
ENSG00000204103
|
MAFB
|
2.97
|
4.66 × 10−3
|
↓
|
|
ENSG00000148344
|
PTGES
|
2.92
|
8.29 × 10−3
|
↑
|
|
ENSG00000041982
|
TNC
|
2.80
|
8.51 × 10−3
|
↑
|
|
ENSG00000141753
|
IGFBP4
|
2.59
|
3.50 × 10−2
|
↑
|
|
ENSG00000160111
|
CPAMD8
|
0.39
|
4.98 × 10−2
|
↓
|
|
ENSG00000166165
|
CKB
|
0.38
|
1.04 × 10−2
|
↑
|
|
ENSG00000106258
|
CYP3A5
|
0.38
|
3.62 × 10−2
| |
|
ENSG00000107736
|
CDH23
|
0.37
|
6.88 × 10−3
| |
|
ENSG00000187720
|
THSD4
|
0.35
|
1.44 × 10−2
| |
|
ENSG00000144908
|
ALDH1L1
|
0.33
|
2.22 × 10−3
|
↓
|
|
ENSG00000092758
|
COL9A3
|
0.32
|
4.89 × 10−2
| |
|
ENSG00000162998
|
FRZB
|
0.32
|
8.51 × 10−3
|
↓
|
|
ENSG00000170891
|
CYTL1
|
0.32
|
4.11 × 10−2
| |
|
ENSG00000064205
|
WISP2
|
0.31
|
1.08 × 10−3
|
↓
|
|
ENSG00000082196
|
C1QTNF3
|
0.30
|
3.64 × 10−2
|
↑
|
|
ENSG00000122756
|
CNTFR
|
0.27
|
1.44 × 10−2
|
↓
|
|
ENSG00000165966
|
PDZRN4
|
0.26
|
1.44 × 10−2
|
↓
|
|
ENSG00000167779
|
IGFBP6
|
0.19
|
3.07 × 10−4
| |
- aTo correct for multiple testing, the Benjamini-Hochberg method was applied to P-values and reported as the false discovery rate (FDR). bGene expression changes measured in RNA-sequencing data between preserved and lesioned OA articular cartilage, with preserved as reference [5]. Legend: FC fold change, FDR false discovery rate
