Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Table 1 Top 20 genes with the highest absolute FC in 65% mechanically stressed cartilage compared to controls

Ensemble ID	Gene name	FC	FDR^a	Differential expression in OA cartilage [5]^b
ENSG00000115461	IGFBP5	6.01	7.81 × 10⁻³
ENSG00000137745	MMP13	5.19	4.84 × 10⁻²
ENSG00000204103	MAFB	2.97	4.66 × 10⁻³	↓
ENSG00000148344	PTGES	2.92	8.29 × 10⁻³	↑
ENSG00000041982	TNC	2.80	8.51 × 10⁻³	↑
ENSG00000141753	IGFBP4	2.59	3.50 × 10⁻²	↑
ENSG00000160111	CPAMD8	0.39	4.98 × 10⁻²	↓
ENSG00000166165	CKB	0.38	1.04 × 10⁻²	↑
ENSG00000106258	CYP3A5	0.38	3.62 × 10⁻²
ENSG00000107736	CDH23	0.37	6.88 × 10⁻³
ENSG00000187720	THSD4	0.35	1.44 × 10⁻²
ENSG00000144908	ALDH1L1	0.33	2.22 × 10⁻³	↓
ENSG00000092758	COL9A3	0.32	4.89 × 10⁻²
ENSG00000162998	FRZB	0.32	8.51 × 10⁻³	↓
ENSG00000170891	CYTL1	0.32	4.11 × 10⁻²
ENSG00000064205	WISP2	0.31	1.08 × 10⁻³	↓
ENSG00000082196	C1QTNF3	0.30	3.64 × 10⁻²	↑
ENSG00000122756	CNTFR	0.27	1.44 × 10⁻²	↓
ENSG00000165966	PDZRN4	0.26	1.44 × 10⁻²	↓
ENSG00000167779	IGFBP6	0.19	3.07 × 10⁻⁴

^aTo correct for multiple testing, the Benjamini-Hochberg method was applied to P-values and reported as the false discovery rate (FDR). ^bGene expression changes measured in RNA-sequencing data between preserved and lesioned OA articular cartilage, with preserved as reference [5]. Legend: FC fold change, FDR false discovery rate

ISSN: 1478-6362