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Table 2 Gene ontology and pathway enrichment analysis of differentially expressed genes in mechanically stressed cartilage

From: Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Term

Entry

Overlap

Adj P-valuea

Odds ratio

Genes

Cellular senescence

hsa04218

8/160

1.15 × 10−2

6.41

GADD45A, MYC, SERPINE1, AKT3, EIF4EBP1, SLC25A5, ETS1, FOXO1

Focal adhesion

hsa04510

8/199

1.33 × 10−2

5.15

SHC4, CAV1, ITGA10, AKT3, LAMA3, TNC, COL9A3, TLN2

Insulin-like growth factor II binding

GO:0031995

3/7

1.83 × 10−2

54.95

IGFBP5, IGFBP4, IGFBP6

Focal adhesion

GO:0005925

11/356

2.54 × 10−2

3.96

ENAH, EHD3, GSN, CAV1, TNC, CD9, TLN2, RPL10A, DCAF6, RHOB, ENG

Insulin-like growth factor I binding

GO:0031994

3/13

2.89 × 10−2

29.59

IGFBP5, IGFBP4, IGFBP6

  1. aEnrichr uses a modified Fisher’s exact test to compute enrichment and this is reported as the adjusted P-value [29]. Legend: Adj P-value, adjusted P-value