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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging

Fig. 1

Young and old mice are similarly susceptible to G6PI-induced arthritis. Young (average age of 10 weeks, n=74) or old (average age of 96 weeks, n=26) DBA/1 mice were immunized with G6PI. Arthritis severity was scored after immunization. a The scores were summarized in the diagram in intervals with the average time point indicated on the x-axis. b Score at day 9 is shown separately. c Percentage of mice developing arthritis of low severity (max. score < 5), intermediate severity (max. score of 5–20) or strong severity (max. score > 20). d–f Before induction and after recovery from arthritis, synovial cells of the small joints were extracted and total number of all cells recovered (d), CD45+ cells or CD45- cells (e), and CD90+CD45- or CD90-CD45- cells were determined (f). Individually analyzed mice were grouped into young d0 (average age of 16 weeks, n=8), young d56 (average age of 25 weeks, n=5), old d0 (average age of 66 weeks, n=4), or old d56 (average age of 89 weeks, n=6). g Young B6.NQ (open circles, average age of 10 weeks, n=49), generation 4 B6.NQ/Terc-/- (gray diamonds, average age of 40 weeks, n=16), or old B6.NQ (dark gray squares, average age of 70 weeks, n=11) mice were immunized with G6PI in CFA s.c.. Arthritis was scored for 42 days. h Score of the day 9 interval is separately shown as box plot (n.d. = not detectable). Statistical testing was performed as described in the methods section. n.s. non-significant

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