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Table 1 Characteristics of baseline and first 2-year course factors

From: Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort

Factors Baseline, presented positive
N (%)
Decrease/negative at both time points
N (%)
Stable/positive at either time point
N (%)
Increase/positive at both time points
N (%)
BMI 26.3 (4.2)c 154 (13) 892 (75) 139 (12)
Bilateral knee pain 848 (72) 152 (13) 447 (37) 586 (50)
Joint line tenderness 528 (45) 541 (45) 390 (33) 254 (22)
Bony swelling 43 (4) 1092 (92) 88 (7) 5 (1)
Joint warmth 48 (4) 1103 (93) 77 (6) 5 (1)
Joint effusion 80 (7) 1042 (88) 137 (11) 6 (1)
PF joint crepitus 533 (45) 500 (42) 319 (27) 366 (31)
PF joint grinding 370 (31) 727 (61) 320 (27) 138 (12)
Restricted/painful flexion 327 (30) 359 (30) 458 (39) 368 (31)
Restricted/painful extension 606 (51) 706 (60) 360 (30) 119 (10)
Heberden nodes 604 (52) 384 (32) 270 (23) 531 (45)
WOMAC paina
 Walking 202 (17) 273 (23) 664 (56) 248 (21)
 Standing 249 (21) 248 (21) 652 (55) 285 (24)
 Stairs 569 (48) 332 (28) 592 (50) 261 (22)
 Night 379 (32) 380 (32) 545 (46) 260 (22)
 Rest 308 (26) 320 (27) 628 (53) 237 (20)
WOMAC functiona
 Descending 355 (30) 332 (28) 593 (50) 260 (22)
 Ascending 486 (41) 332 (28) 569 (48) 284 (24)
 Rising 438 (37) 320 (27) 640 (54) 225 (19)
 Standing 225 (19) 237 (20) 675 (57) 273 (23)
 Walking 166 (14) 236 (20) 712 (60) 237 (20)
 Sitting 178 (15) 263 (22) 687 (58) 235 (20)
WOMAC morning stiffnessa 590 (50) 379 (32) 545 (46) 261 (22)
Medial TF osteophyteb 130 (11) 20 (2) 950 (80) 215 (18)
Lateral TF osteophyteb 189 (16) 10 (1) 904 (76) 271 (23)
Medial TF JSNb 73 (6) 24 (2) 960 (81) 201 (17)
Lateral TF JSNb 11 (1) 35 (3) 1045 (88) 105 (9)
PF osteophyteb 130 (11) 23 (2) 1055 (89) 107 (9)
PF JSNb 36 (3) 9 (1) 955 (81) 221 (18)
TF angle − 1.8 (1.8)c 305 (26) 761 (64) 119 (10)
  1. BMI, body mass index; PF joint, patellofemoral joint; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; TF, tibiofemoral; JSN, joint space narrowing; percentages are calculated by dividing total number of knees (1185)
  2. aAll the WOMAC items have 5 grades (0 to 4). Patient graded at 2 or more were treated as positive presentation at baseline
  3. bRadiographic items were graded according to Kellgren & Lawrence criteria with 5 grades (0–4), and grade 2 or more was treated as positive presentation at baseline
  4. cPresented as mean (standard deviation)