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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients

Fig. 2

Anti-citrullinated hnRNP-DLmir autoantibodies are detectable even before the onset and in early status of disease. AC Anti-citrullinated hnRNP-DLmir (cit-DL), α-hnRNP-DLmir (DL) and ∆ OD between cit-DL and DL (ΔDL) were measured by ELISA. A In Risk-patients of arthritis the OD levels of cit-DL and ΔDL before onset are significantly specific in the patient group where the arthritis has already been diagnosed compared to the group without diagnosis (n = 71; non-arthritis n = 34/arthritis n = 37; Mann-Whitney U; cit-DL mediannon Arthritis = 0.19/medianArthritis = 0.46; p = 0.0006; NC-index mediannon Arthritis = 0.10/medianArthritis = 0.38; p = 0.0003). B, C Cit-DL and ΔDL are significantly associated with parenchymal changes in the lung of early RA patients of the LURA cohort (B; n = 106; no n = 48/PC n = 58; Mann-Whitney U; cit-DL medianno = 0.23/medianPC = 0.53; p = 0.0340; NC-index medianno = 0.16/medianPC = 0.44; p = 0.0332) and with and shared epitopes of the early RA patients of the EIRA cohort (C; n = 404; no n = 112/SE n = 213/double SE n = 79; Mann-Whitney U; cit-DL medianno = 0.27/medianSE = 0.36; p = 0.0003, medianno = 0.27/mediandouble SE = 0.54; p < 0.0001, medianSE = 0.36/mediandouble SE = 0.54; p = 0.0453; NC-index medianno = 0.11/medianSE = 0.21; p < 0.0001, medianno = 0.11/mediandouble SE = 0.34; p < 0.0001, medianSE = 0.21/mediandouble SE = 0.34; p = 0.0061). Mann-Whitney U test was performed for analysing significance of indicated groups (*p < 0.05, **p < 0.01, ***p < 0.001 ****p < 0.0001). OD, optical density; ns, not significant; PC, parenchymal changes in lung; SE, shared epitope

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