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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients

Fig. 3

Diagnostic performance of α-hnRNP-DLmir (DL) for the detection of therapy response. High baseline titre against α-hnRNP-DLmir (DL) is rather present in 6-month EULAR Responder RA patients who had received MTX or α-TNF inhibitor therapy (Enbrel®). AC α-DL were measured by ELISA in patient sera from the EIRA cohort treated with MTX (n = 192) with 161 EULAR responder and 31 EULAR non-responder among 6 months. Above these values, ROC analyses were performed for detecting DAS28 therapy response. DF α-DL were measured by ELISA in patient sera from the predict cohort treated with Enbrel® therapy with 6-month EULAR response data (n = 94, responder n = 63, non-responder n = 31). Based on the signals, ROC analysis was performed for detecting DAS28 therapy response. OD, optical density; vs., versus; RA, rheumatoid arthritis; MTX, methotrexate; seropos., rheumatoid factor IgM and/or α-CCP-2 positive patients; seroneg., rheumatoid factor IgM and α-CCP-2 negative patients

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