Fig. 4

GO enrichment analysis and the levels of complement C3 in LN patients. A Directed acyclic graph of GO enrichment, showing upregulated genes in biological process in LN patients and NZB/W mice. Squares: complement-related GO terms; red squares or red circles: significant enrichment; # significant enrichment only in LN patients; ## significant enrichment only in NZB/W mice; the unmarked terms: have significant enrichment in LN patients and NZB/W mice. B Levels of urinary C3 in healthy controls (N = 11), SLE patients without LN (N = 14) and patients with LN (N = 39). *** p < 0.001. C Levels of plasma C3 in SLE patients without LN (N = 66) and patients with LN (N = 76). *** p < 0.001. D Correlation between the urinary levels of C3 and 24 h urine protein (N = 37)