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Table 1 Details of the four significantly different GO terms associated with complement

From: Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis

Species GO_ID GO_Name Population_mapped_id Study_mapped_id Gene_symbol Description Enrichment p value FDR
Human GO:0001869 Negative regulation of complement activation, lectin pathway 2 2 SERPING1, A2M Serpin family G member 1, alpha-2-macroglobulin 14.158 0.005 0.062
Mouse GO:0001869 Negative regulation of complement activation, lectin pathway 2 2 Serping1, A2m Serine (or cysteine) peptidase inhibitor, clade G, member 1, alpha-2-macroglobulin 21.701 0.002 0.019
Human GO:0002430 Complement receptor-mediated signaling pathway 9 3 FPR1, FPR2, C3AR1 Formyl peptide receptor 1, formyl peptide receptor 2, complement C3a receptor 1 4.719 0.021 0.153
Mouse GO:0002430 Complement receptor-mediated signaling pathway 11 4 Fpr1, C3ar1, Fpr2, C5ar1 Formyl peptide receptor 1, complement component 3a receptor 1, formyl peptide receptor 2, complement component 5a receptor 1 7.891 0.001 0.013
Human GO:0030449 Regulation of complement activation 29 7 C5AR1, C3, C3AR1, C1QBP, CFH, CFP, PROS1 Complement C5a receptor 1, complement C3, complement C3a receptor 1, complement C1q binding protein, complement factor H, complement factor properdin, protein S (alpha) 3.417 0.003 0.052
Mouse GO:0006957 Complement activation, alternative pathway 10 3 C3, Cfh, Cfp Complement component 3, complement component factor h, complement factor properdin 6.510 0.009 0.055
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Arthritis Research & Therapy

ISSN: 1478-6362

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