Table 1 Details of the four significantly different GO terms associated with complement
Species | GO_ID | GO_Name | Population_mapped_id | Study_mapped_id | Gene_symbol | Description | Enrichment | p value | FDR |
|---|---|---|---|---|---|---|---|---|---|
Human | GO:0001869 | Negative regulation of complement activation, lectin pathway | 2 | 2 | SERPING1, A2M | Serpin family G member 1, alpha-2-macroglobulin | 14.158 | 0.005 | 0.062 |
Mouse | GO:0001869 | Negative regulation of complement activation, lectin pathway | 2 | 2 | Serping1, A2m | Serine (or cysteine) peptidase inhibitor, clade G, member 1, alpha-2-macroglobulin | 21.701 | 0.002 | 0.019 |
Human | GO:0002430 | Complement receptor-mediated signaling pathway | 9 | 3 | FPR1, FPR2, C3AR1 | Formyl peptide receptor 1, formyl peptide receptor 2, complement C3a receptor 1 | 4.719 | 0.021 | 0.153 |
Mouse | GO:0002430 | Complement receptor-mediated signaling pathway | 11 | 4 | Fpr1, C3ar1, Fpr2, C5ar1 | Formyl peptide receptor 1, complement component 3a receptor 1, formyl peptide receptor 2, complement component 5a receptor 1 | 7.891 | 0.001 | 0.013 |
Human | GO:0030449 | Regulation of complement activation | 29 | 7 | C5AR1, C3, C3AR1, C1QBP, CFH, CFP, PROS1 | Complement C5a receptor 1, complement C3, complement C3a receptor 1, complement C1q binding protein, complement factor H, complement factor properdin, protein S (alpha) | 3.417 | 0.003 | 0.052 |
Mouse | GO:0006957 | Complement activation, alternative pathway | 10 | 3 | C3, Cfh, Cfp | Complement component 3, complement component factor h, complement factor properdin | 6.510 | 0.009 | 0.055 |