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Table 1 Characteristics of the single cell sorted AMPA-IgM expressing B cell sequences. IGHVDJ, IGLVJ and number of IGHV mutations were determined by alligment to the IMGT database

From: Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

  2D5 1G8 1E3 Anti-TT
Antigen for isolation CCP2 CCP2 Acetylated-vimentin (HC55) Tetanus Toxoid
Patient 5 5 6 7
Heavy chain μ μ μ μ
IGHV V7-4-1 V7-4-1 V4-59 V5-10-1
IGHD D4-17 D7-27 D5-24 D3-10
IGHJ J6 J4 J6 J3
IGH-CD3
aa
CARGTHDYADYYYYGMDVW CARGTEDGDAYFDYW CARHIQSLVTTGYYTYPMDVW CARSYYGPGNYDAFDIW
#IGHV mutations nt 3 7 16 16
Light chain λ λ κ κ
IGLV V10-54 V4-69 V2-28 V1-9
IGLJ J3 J2 J2 J4
IGL-CDR3aa CSAWDNSLSAWVF CQTWGTDTVVF CMQALQNPRAF CQQLHSYPRTF
#IGLV mutations nt 4 8 7 9