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Table 3 Spearman cross-correlations of biomarkers

From: A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis

 

Serum hsCRP

(rs; p)

Serum CRPM

(rs; p)

Serum C1M

(rs; p)

Serum C3M

(rs; p)

Serum hsCRP

–

–

–

–

Serum CRPM

0.182; 0.385

–

–

–

Serum C1M

0.404; 0.045

0.358; 0.079

–

–

Serum C3M

0.202; 0.334

0.818; <0.0001

0.487; 0.014

–

Plasma CRP

0.990; <0.0001

0.192; 0.359

0.423; 0.035

0.211; 0.312

Plasma CD14

−0.021; 0.920

0.358; 0.079

0.232; 0.265

0.363; 0.074

Serum CD163

0.249; 0.231

0.512; 0.009

0.161; 0.443

0.492; 0.013

Plasma MMP-3

−0.119; 0.571

−0.130; 0.536

−0.178; 0.395

−0.181; 0.388

Plasma MMP-9

−0.152; 0.470

−0.107; 0.611

0.205; 0.325

0.096; 0.649

Plasma TIMP-1

−0.140; 0.505

−0.217; 0.297

−0.180; 0.389

−0.207; 0.321

Plasma TIMP-1: MMP-3

−0.002; 0.994

0.014; 0.948

0.007; 0.974

−0.069; 0.742

SF MMP-3*

−0.335; 0.174

0.053; 0.836

0.051; 0.842

0.129; 0.610

SF MMP-9*

0.038; 0.882

−0.118; 0.640

0.158; 0.531

−0.223; 0.375

SF Neutrophil Elastase**

−0.247; 0.337

0.061; 0.815

−0.118; 0.651

0.149; 0.567

SF CD14*

−0.233; 0.367

0.2451; 0.342

0.240; 0.352

0.248; 0.337

SF CD163*

−0.207; 0.409

0.513; 0.030

0.065; 0.798

0.562; 0.015

  1. Bolded correlations were significant (p<0.05)
  2. SF synovial fluid, serum hsCRP measured by ELISA (MP Biomedicals), plasma CRP measured by Luminex-based InflammationMAP 1.0 assay (RBM)
  3. *n=18; **n=17