Fig. 4

Copy numbers of SE alleles and remission in DAS28-ESR. The percentage of patients in DAS28-ESR remission stratified according to the copy numbers of SE alleles are shown 4, 12, and 24 weeks after the start of treatment with tofacitinib (A) or abatacept (B). The effects of the copy numbers of SE alleles on the percentage of patients achieving remission in DAS28-ESR at 24 weeks in each treatment group were assessed by the Cochran-Armitage test; not significant for tofacitinib, p = 0.00309 for abatacept. DAS28-ESR, Disease Activity Score in 28 joints using the erythrocyte sedimentation rate; SE 0, 0 copies of shared epitope alleles; SE 1, 1 copy of shared epitope alleles; SE 2, 2 copies of shared epitope alleles