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Table 2 Key efficacy outcomes at week 16 in the CRP−/MRI+ subgroup by screening SIJ MRI score

From: Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT

Endpoints, % responders (n/M)

Screening SIJ MRI score

Pooled secukinumab 150 mg

Placebo

ASAS40

< 2

31.7 (26/82)

30.0 (12/40)

≥ 2

42.5 (31/73)

32.5 (13/40)

ASAS PR

< 2

14.6 (12/82)

7.5 (3/40)

≥ 2

24.7§ (18/73)

7.5 (3/40)

ASDAS-CRP ID

< 2

17.1 (14/82)

15.0 (6/40)

≥ 2

30.1 (22/73)

12.5 (5/40)

  1. NRI data presented for all variables
  2. The total number of patients in the screening MRI score of < 2 subgroup was 82 (pooled secukinumab 150 mg) and 40 (placebo) and in the screening MRI score ≥ 2 subgroup was 73 (pooled secukinumab 150 mg) and 40 (placebo)
  3. ASAS Assessment of SpondyloArthritis international Society, ASDAS Ankylosing Spondylitis Disease Activity Score, CRP C-reactive protein, ID inactive disease, M number of evaluable patients, MRI magnetic resonance imaging, NRI non-responder imputation, PR partial remission, SIJ sacroiliac joint
  4. §P < 0.01, P < 0.05 versus placebo