Fig. 2

IPRN ameliorated the arthritis phenotype of the CIA model. Mice with CIA (n=9) received an intraperitoneal injection of IPRN (5 mg/kg or 20 mg/kg) every 2 days. a Representative image of hind paws. b, c Paw thickness and arthritis score. d Micro-CT of ankles. e H&E staining and quantification of histological score of ankle samples. f The serum levels of IL-6, IL-1β, COMP, and IL-10. The data are expressed as the mean ± SD (n=9). ^*P < 0.05, ^**P < 0.01, and ^***P< 0.001