Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Isopsoralen ameliorates rheumatoid arthritis by targeting MIF

Fig. 3

Molecular pathway prediction of the antiarthritic effect of IPRN in RA FLSs by RNA-Seq. RA FLSs were treated without or with IPRN (10 μM) in the presence of TNF-α (10 ng/mL) for 24 h. Total RNA was extracted for RNA-seq. a The number of differentially expressed genes (DEGs) induced by IPRN. b Heatmap displays different blocks of top 20 DEGs between the IPRN-treated cells (n=3) and the control cells (n=3). c The GO analysis of DEGs induced by IPRN. Bar plots show the significant enrichment terms of the DEGs involving biological process, cellular component, and molecular function ranked by enrichment score (−log10 (p value)) values. d KEGG enrichment of DEGs. e Verification of DEGs by RT-qPCR. The data are expressed as the mean ± SD (n=6). *P<0.05, ***P < 0.001

Back to article page