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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint

Fig. 5

Differences in monocyte transcriptomes between nr-axSpA and AS patients. Five hundred and sixty-two significant probe-sets (HPCDA score > 100) were identified by comparing monocyte transcriptomes of nr-axSpA patients (n = 10) and AS patients (n = 15) of cohort 1. A Hierarchical clustering and B principal component analysis using 562 significant differentially expressed probe-sets of 10 nr-axSpA patients and 15 AS patients. C Overlap of upregulated and downregulated probe-sets with the indicated functional groups according to GSEA based on MSigDB as input database. D Co-expression analysis performed as in Fig. 2 of probe-sets upregulated in AS patients in reference transcriptomes from bone marrow and blood cells. E Co-expression analysis of probe-sets downregulated in AS patients in reference transcriptomes. Red indicated increased signal expression (max = 2) or positive correlation (max = 1) and blue indicates decreased signal expression (min = − 2) or negative correlation (min = − 1)

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