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Table 1 Characteristics of axSpA patient cohorts

From: Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint

 

Cohort 1

Cohort 2

axSpA (n = 25)

HC (n = 10)

axSpA (n = 32)

HC (n = 22)

nr-axSpA (n = 10)

AS (n = 15)

nr-axSpA (n = 9)

AS (n = 23)

Age [years], mean (± SD)

34.4 (± 8.8)

40.4 (± 11.4)

35.5 (± 9.6)

49.2 (± 11.8)

51.4 (± 8.5)

52.5 (± 11.9)

Sex [male], n (%)

5 (50)

10 (66.7)

5(50)

5 (56)

15 (65)

2 (9)

Disease duration [years], mean

5.7

10.6

-

26.9

30

-

BASDAI, mean (± SD)

3.8 (± 2.2)

4.2 (± 1.9)

-

4.6 (± 1.6)

3.4 (± 2.3)

-

BASDAI ≥ 4, n (%)

3 (30)

9 (60)

-

6 (67)

10 (43)

-

ASDAS-CRP, mean (± SD)

2.0 (± 0.9)

2.3 (± 0.8)

-

n.a.

n.a.

-

CRP [mg/l], mean (± SD)

0.9 (± 0.9)

5.1* (± 6.4)

1.5 (± 1.6)

n.a.

n.a.

-

Uveitis#, n (%)

1 (10)

3 (20)

-

0 (0)

9 (39)

-

Arthritis#, n (%)

5 (50)

1 (7)

-

6 (67)

14 (61)

-

Enthesitis#, n (%)

4 (40)

4 (27)

-

9 (100)

15 (65)

-

Psoriasis#, n (%)

4 (40)

3 (20)

-

1 (11)

3 (13)

-

IBD#, n (%)

0 (0)

0 (0)

 

0 (0)

0 (0)

-

  1. n.a. not available
  2. *p < 0.05 vs. nr-axSpA (Mann-Whitney U test)
  3. #Acute and past manifestations