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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy

Fig. 1

Genome-wide SNP and DNA methylation analysis between the HLF group and the CT group. A Waterfall graph of the SNPs. The x-axis represents the sample names, of which the first five belong to the CT group and the ladder five belong to the HLF group. The left y-axis represents the percentage of the major SNP type in the total ones. The right y-axis represents the gene names. The colors represent the SNP types. Red means missense; light blue means synonymous; green means stoploss; and dark blue means stopgain. B Heatmap showing the top 50 differentially methylated sites. C Manhattan plot showing the distribution of the differentially methylated sites. D Pie chart showing the composition of the differentially methylated sites’ locations among the genome. “Body” represents genes’ introns and exons. “IGR” represents the intergenic region. “TSS 1500” represents 1500 bp ahead of the transcription start site (TSS). “TSS 200” represents 200 bp ahead of the transcription start site (TSS). “UTR” represents the untranslated region. “ExonBnd” represents the border of the exons

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Arthritis Research & Therapy

ISSN: 1478-6362

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