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Table 2 Comparison of catastrophic AOSD patients and controls

From: Catastrophic adult-onset Still’s disease as a distinct life-threatening clinical subset: case–control study with dimension reduction analysis

 

Catastrophic AOSD, n = 20

Control AOSD, n = 41

Univariate analysis

Multivariate analysis

Model 1

Model 2

p

p

Odds ratio

CI 95%

p

Odds ratio

CI 95%

Age

33 (18–64)

40.5 (18–79)

0.01

0.013

0.94

0.9–0.98

   

Male

12 (60%)

18 (44%)

0.24

      

Time from first symptoms to hospitalisation

10 (1–61)

20 (1–85)

0.005

   

0.04

0.95

0.9–0.99

Fever

19 (95%)

41 (100%)

0.99

      

Rash

13 (65%)

35 (85%)

0.07

      

Sore throat

13 (65%)

27 (66%)

0.95

      

Arthromyalgia

17 (85%)

37 (90%)

0.377

      

 Arthralgia

10 (50%)

34 (83%)

0.01

0.005

0.13

0.02–0.49

0.017

0.2

0.05–0.93

 Arthritis

3 (15%)

19 (46%)

0.02

      

 Myalgia

11 (55%)

21 (52%)

0.78

      

Hepatomegaly

11 (55%)

13 (32%)

0.08

      

Splenomegaly

9 (45%)

8 (19%)

0.04

      

Adenopathy

10 (50%)

14 (34%)

0.23

      

Pleuritis

5 (25%)

7 (17%)

0.47

      

Pericarditis

3 (15%)

8 (19%)

0.66

      

Lung infiltrate

7 (35%)

2 (5%)

0.006

      

Myocarditis

8 (40%)

3 (7%)

0.005

      

Heart rate (/min)

108 (73–150)

95 (70–125)

0.03

      

Leukocytes (× 109/mL)

16 (1–28)

12 (2–35)

0.11

      

Haemoglobin (g/dL)

12 (10–14)

11 (9–14)

0.95

      

Platelets (× 109/mL)

262 (142–521)

271 (88–608)

0.47

      

Prothrombin time (%)

70 (40–110)

81 (39–123)

0.23

      

ASAT (UI/L)

51 (14–615)

51.5 (13–280)

0.25

      

ALAT (UI/L)

34 (7–430)

37.5 (6–433)

0.65

      

Creatinine (μmol/L)

73 (46–274)

71 (49–314)

0.46

      

CRP (mg/L)

272 (61–495)

151 (3–416)

0.009

      

Ferritin (ng/mL)

27,153 (655–147,568)

6680 (117–49,997)

0.014

      
  1. AOSD, adult-onset Still’s disease; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; CRP, C-reactive protein; CI, confidence interval; frequency (%); median (min–max)
  2. Variables included in the multivariate analysis: sex, age, age > 50 years, time from first symptoms to hospitalisation, rash, sore throat, arthralgia, arthromyalgia, arthritis, myalgia, hepatomegaly, splenomegaly, adenopathy, pleuritis, lung infiltrate, pericarditis, hepatitis, leukocytes, haemoglobin, platelets, CRP, ferritin and creatinine