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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?

Fig. 3

SSc-Cont differences for the serum proteins are significantly associated with SSc-Cont differences in skin. a SSc-Cont differences are positively correlated between serum proteins and corresponding skin transcripts. b WAP score ranks of differentially expressed serum proteins for SSc-Cont differences in skin and in PBC (lower values of rank represent more significant WAPs). c Ratios of observed to expected counts of pathway network connections between differentially expressed serum proteins and top 50, 100, and 250 most differentially expressed transcripts in SSc vs. Cont comparisons in skin (cyan) and in PBC (pink) and corresponding edge-count probabilities. Horizontal dashes (green) in c represent unremarkable case of the count of observed edges being equal to that expected for randomly rewired pathway network under null model of random graph with given expected degrees

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