Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?

Table 3 Serum proteins significantly associated with modified Rodnan Skin Score (FDR < 0.05)

Protein name	Uniprot accession	p^a	ρ^b	ρ_part^c	SSc-Cont^d
Cytokines
CCL18	P55774	0.001	0.4	0.48
GDF-8	O14793	0.002	− 0.32	− 0.45
CCL3	P10147	0.001	0.3	0.31
ECM proteins
NOV	P48745	< 0.001	0.56	0.54	Up
SMOC2	Q9H3U7	< 0.001	0.55	0.51
Enzymes
CA6	P23280	< 0.001	− 0.42	− 0.48
PCSK9	Q8NBP7	0.001	− 0.5	− 0.46
DDC	P20711	0.002	− 0.38	− 0.37
Growth factor receptors
EGFR	P00533	< 0.001	− 0.5	− 0.54	Down
DNER	Q8NFT8	< 0.001	− 0.4	− 0.43	Down
ERBB4	Q15303	0.001	− 0.4	− 0.38
NTRK2	Q16620	0.001	− 0.39	− 0.34	Down
Growth factors
VEGFD	O43915	0.001	− 0.48	− 0.45
PGF	P49763-3	0.002	0.45	0.39	Up
VEGFA	P15692	0.002	0.39	0.39
Integrins
ITGAV	P06756	< 0.001	− 0.49	− 0.47	Down
ITGB1	P05556	0.002	− 0.41	− 0.36
Lectin
Gal-4	P56470	0.001	− 0.53	− 0.52
Others
RCOR1	Q9UKL0	< 0.001	0.61	0.66
THBS4	P35443	< 0.001	0.59	0.58	Up
PSIP1	O75475	< 0.001	0.56	0.55
ALCAM	Q13740	0.001	− 0.59	− 0.54
ADGRG2	Q8IZP9	0.001	− 0.56	− 0.54	Down
ENAH	Q8N8S7	0.001	0.5	0.5
IGFBP6	P24592	0.002	− 0.5	− 0.5	Down
CD177	Q8N6Q3	0.001	0.42	0.47
CD58	P19256	0.002	− 0.48	− 0.46
SOST	Q9BQB4	< 0.001	− 0.38	− 0.46	Down
LYN	P07948	0.001	0.38	0.45
DPP6	P42658	0.001	− 0.45	− 0.44
Ep-CAM	P16422	0.001	− 0.45	− 0.44	Down
TF	P13726	0.001	− 0.43	− 0.43
ZBTB17	Q13105	< 0.001	0.43	0.42
LAYN	Q6UX15	0.001	0.41	0.41	Up
TRAIL	P50591	0.001	− 0.4	− 0.4	Down
IL-1RT2	P27930	0.001	− 0.35	− 0.39
PECAM-1	P16284	0.001	− 0.21	− 0.31
TNF receptor superfamily
TRAIL-R2	O14763	0.001	0.5	0.49	Up
TNFRSF12A	Q9NP84	0.001	0.36	0.45

^aThe significance of association from multiple linear regression model after adjustment for age and gender
^bSpearman correlation between mRSS and protein expression
^cPartial (adjusted for age and gender) Spearman correlation between mRSS and protein expression
^dDirection of SSc-Cont differential expression (if significant)

ISSN: 1478-6362