Fig. 5
From: Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis
Decreased subchondral bone thickness in rapamycin and rapamycin plus metformin-treated guinea pigs. Representative microCT sagittal cross sections from the medial aspect of the joint are shown (A). Subchondral cortical thickness was measured in the medial and lateral tibial plateaus and femoral condyles (B), and cortical thickness was measured in the femoral diaphysis (C). Medial tibial cortical thickness relative to femoral diaphyseal cortical thickness was found to be similar between groups (D). Medial tibial cortical thickness was highly correlated to bodyweight (E). Femoral epicondylar width was found to be similar between groups (F). N = 4 per group. Data analyzed using a one-way ANOVA to detect differences between groups. Correlations assessed by Pearson correlation. Shaded bands represent 95% CI. *P < 0.05 vs Con, **P < 0.01 vs Con