Table 2 Concentrations of rapamycin and metformin in circulation. Whole blood was collected ~ 3 h after food had been removed from the cages of guinea pigs and was analyzed for rapamycin and metformin concentration by tandem HPLC/MS. N = 4 per group. The blood concentration of rapamycin and metformin in the control group were below the detectable limits of the HPLC/MS/MS. Data are presented as mean ± SD
From: Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis
Experimental Diet | |||
|---|---|---|---|
Control | Rapamycin | Rapamycin+Metformin | |
Circulating rapamycin (ng/mL) | < 0.5 ± 0 | 72 ± 8 | 78 ± 10 |
Circulating metformin (ng/mL) | < 4 ± 0 | - | 282 ± 54 |