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Table 2 Concentrations of rapamycin and metformin in circulation. Whole blood was collected ~ 3 h after food had been removed from the cages of guinea pigs and was analyzed for rapamycin and metformin concentration by tandem HPLC/MS. N = 4 per group. The blood concentration of rapamycin and metformin in the control group were below the detectable limits of the HPLC/MS/MS. Data are presented as mean ± SD

From: Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

  Experimental Diet
Control Rapamycin Rapamycin+Metformin
Circulating rapamycin (ng/mL) < 0.5 ± 0 72 ± 8 78 ± 10
Circulating metformin (ng/mL) < 4 ± 0 - 282 ± 54