Fig. 2

Typical LS301 biodistribution in arthritic mice. A Example ex vivo organ biodistribution of LS301 in C57BL/6J mice with serum transfer arthritis (left) or in control C57BL/6J mice (right) 18h after intravenous injection, as assessed by near-infrared fluorescence imaging on the Pearl animal imaging system. C57BL/6J mice with serum arthritis (days 5–6 post serum transfer) (left) or control C57BL/6J mice (right) were injected intravenously with 6 nmol LS301. Organs were harvested at 18h post injection. Near-infrared fluorescence images were taken on the Pearl animal imaging system with λ = 820 nm. Arrows denote detected areas of joint inflammation. B Quantification of fluorescence from individual organs from (A) (n = 4 mice per group). ROIs were drawn around each organ/limb of interest and quantitated using the Pearl animal imaging system software