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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes

Fig. 7

LS301 association with cartilage damage. K/BxN F1 mice (6–7 weeks old) (n = 2 mice per group) were injected intravenously with 6 nmol LS301. Six hours after LS301 injection, paws and ankles were harvested and frozen for sectioning. Sections were stained with Safranin O/Fast Green and viewed for LS301 fluorescence by microscopy under the cypate channel (Ex/Em 775±25nm/845±28nm). A Images from regions associated with pannus/bone erosion. Arrows indicate areas of LS301 accumulation. B Images showing preferential association of LS301 with regions of cartilage damage (loss of Safranin O staining). Arrows indicate areas of LS301 accumulation

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Arthritis Research & Therapy

ISSN: 1478-6362

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