Table 3 Associations of clinical characteristics with QTc ≥ 440 ms in combined SLE/RA cohort
From: Hydroxychloroquine use is not associated with QTc length in a large cohort of SLE and RA patients
Clinical covariates | Univariable model QTc ≥ 440 ms | Multivariable model QTc ≥ 440 msb | ||||
|---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | |
Age | 1.02 | 1.00–1.03 | 0.004 | 1.00 | 0.99–1.02 | 0.53 |
Sex | 1.29 | 0.86–1.96 | 0.22 | ---------- | ---------- | ---------- |
Race (white vs non-white) | 1.48 | 1.07–2.03 | 0.016 | 1.06 | 0.68–1.63 | 0.80 |
Disease duration (square root) | 0.96 | 0.86–1.07 | 0.48 | ---------- | ---------- | ---------- |
Current HCQ use | 0.48 | 0.33–0.70 | < 0.01 | 0.77 | 0.48–1.23 | 0.27 |
Current prednisone use | 0.46 | 0.33–0.64 | < 0.01 | 0.56 | 0.34–0.92 | 0.023 |
Current biologic use | 0.83 | 0.58–1.19 | 0.30 | ---------- | ---------- | ---------- |
Hypertension | 1.18 | 0.87–1.61 | 0.29 | ---------- | ---------- | ---------- |
Current smoking | 1.46 | 0.82–2.60 | 0.20 | ---------- | ---------- | ---------- |
Diabetes | 1.64 | 0.95–2.83 | 0.076 | 1.38 | 0.70–2.72 | 0.35 |
Current statin use | 1.08 | 0.73–1.60 | 0.69 | ---------- | ---------- | ---------- |
Current ASA use | 0.51 | 0.36–0.73 | < 0.01 | 0.68 | 0.43–1.07 | 0.095 |
Any QTc meds | 1.07 | 0.78–1.47 | 0.67 | ---------- | ---------- | ---------- |
Antidepressants | 1.79 | 1.07–2.99 | 0.027 | 1.45 | 0.90–2.33 | 0.12 |
Antipsychotics | 1.62 | 0.62–4.22 | 0.33 | ---------- | ---------- | ---------- |
Antiarrhythmics | 1.48 | 0.43–5.06 | 0.53 | ---------- | ---------- | ---------- |
Muscle relaxants | 1.41 | 0.57–3.46 | 0.46 | ---------- | ---------- | ---------- |
Antimicrobials | 0.99 | 0.62–1.58 | 0.97 | ---------- | ---------- | ---------- |
Antiemetics | 1.15 | 0.63–2.08 | 0.65 | ---------- | ---------- | ---------- |
Anticonvulsants | 2.33 | 0.54–1.93 | 0.94 | ---------- | ---------- | ---------- |
Tacrolimus | 1.63 | 0.72–3.69 | 0.24 | ---------- | ---------- | ---------- |
Ejection fraction % | 1.00 | 0.98–1.03 | 0.82 | ---------- | ---------- | ---------- |
Ejection fraction ≥ 55% | 0.81 | 0.44–1.49 | 0.50 | ---------- | ---------- | ---------- |
Prob > F | ---------- | 0.0001 | ||||