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Table 4 Associations of clinical characteristics with QTc ≥ 500 ms in combined SLE/RA cohort

From: Hydroxychloroquine use is not associated with QTc length in a large cohort of SLE and RA patients

Clinical covariates Univariable model QTc ≥ 500 ms Multivariable model QTc ≥ 500 msc
OR 95% CI p OR 95% CI p
Age 0.99 0.961.01 0.25 ---------- ---------- ----------
Sex 1.12 0.492.57 0.79 ---------- ---------- ----------
Race (white vs non-white) 0.92 0.481.76 0.79 ---------- ---------- ----------
Disease duration (square root) 0.86 0.691.07 0.17 ---------- ---------- ----------
Current HCQ use 0.21 0.11–0.44 < 0.01 0.39 0.16–0.98 0.044
Current prednisone use 0.43 0.23–0.81 0.010 0.55 0.231.34 0.19
Current biologic use 0.94 0.481.85 0.86 ---------- ---------- ----------
Hypertension 1.37 0.742.55 0.31 ---------- ---------- ----------
Current smoking 2.71 1.13–6.45 0.025 2.23 0.806.15 0.12
Diabetes 2.73 1.20–6.23 0.017 1.47 0.474.63 0.51
Current statin use 0.56 0.241.29 0.17 ---------- ---------- ----------
Current aspirin use 0.39 0.18–0.83 0.015 0.60 0.231.56 0.29
Any QTc meds 1.14 0.632.07 0.66 ---------- ---------- ----------
Antidepressants 2.41 0.88–6.56 0.085 1.30 0.523.23 0.58
Antipsychotics 1.14 0.139.83 0.90 ---------- ---------- ----------
Antiarrhythmics 2.20 0.2519.67 0.48 ---------- ---------- ----------
Muscle relaxants 3.36 0.80–14.10 0.098 3.04 0.6813.63 0.15
Antimicrobials 0.55 0.152.01 0.36 ---------- ---------- ----------
Antiemetics 1.0 ---------- ---------- ---------- ---------- ----------
Anticonvulsants 1.19 0.1410.29 0.87 ---------- ---------- ----------
Tacrolimus 4.29 0.90–20.33 0.067 4.31 1.06–17.53 0.042
Ejection fraction % 1.07 0.99–1.15 0.060 1.05 0.961.14 0.31
Ejection fraction ≥ 55% 1.79 0.427.63 0.43 ---------- ---------- ----------
Prob > F ---------- 0.0066
  1. Abbreviations: HCQ hydroxychloroquine, QTcMeds QTc prolonging medications
  2. cFinal imputed data