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Table 3 Variables associated with total ASES score across time, based on multivariate linear mixed models

From: Treatment response and several patient-reported outcomes are early determinants of future self-efficacy in rheumatoid arthritis

Variable

Coefficient (95% CI)

p-value

Conditional R2

Interactions

DAS28-CRP

−0.22 (−0.32, −0.11)

<0.001

0.614

HAQ*

HAQ

−1.06 (−1.27, −0.84)

<0.001

0.610

-

Pain (VAS)

−0.14 (−0.19, −0.09)

<0.001

0.603

-

Fatigue (VAS)

−0.15 (−0.19, −0.10)

<0.001

0.606

-

PGA (VAS)

−0.16 (−0.21, −0.11)

<0.001

0.594

-

SF-36 MCS

0.40 (0.29, 0.50)

<0.001

0.607

-

IPQ-R illness coherence

0.12 (0.09, 0.15)

<0.001

0.617

-

IPQ-R treatment control

0.16 (0.12, 0.20)

<0.001

0.619

-

IPQ-R personal control

0.09 (0.06, 0.11)

<0.001

0.608

-

IPQ-R consequences

−0.17 (−0.19, −0.15)

<0.001

0.690

-

IPQ-R emotional representations

−0.11 (−0.12, −0.09)

<0.001

0.634

-

RAQoL

−0.11 (−0.12, −0.09)

<0.001

0.640

HAQ**

PhGA (VAS)

−0.12 (−0.19, −0.04)

0.002

0.613

-

TJC28

−0.01 (−0.06, 0.03)

0.590

0.594

-

SJC28

0.01 (−0.04, 0.07)

0.630

0.594

-

CRP

0.00 (−0.01, 0.01)

0.550

0.594

-

ESR

0.00 (0.00, 0.01)

0.320

0.597

-

  1. Bonferroni correction for multiple comparisons was applied, setting the significance level at p < 0.003
  2. *Interaction (ß = 0.24; 95% CI = 0.12–0.36; p < 0.001) implies that the additional effect of DAS28-CRP on self-efficacy (SE) decreases with increasing HAQ
  3. **Interaction (ß = 0.05; 95% CI = 0.03–0.08; p < 0.001) implies that the additional effect of RAQoL on SE decreases with increasing HAQ
  4. ASES Arthritis Self-Efficacy Scale, DAS28 Disease Activity Score in 28 joints, HAQ Health Assessment Questionnaire, VAS visual analogue scale, PGA patient’s global assessment of disease activity, SF-36 MCS Short-Form 36 mental component score, IPQ-R Revised Illness Perception Questionnaire, PhGA physician’s global assessment of disease activity, TJC28 tender joint count in 28 joints, SJC28 swollen joint count in 28 joints, CRP C-reactive protein, ESR erythrocyte sedimentation rate