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Table 2 Influence of depression on RA disease activity, pain and fatigue over 12 months

From: Baseline predictors of remission, pain and fatigue in rheumatoid arthritis: the TITRATE trial

  

Crude

Adjusteda

β (95%CI)

p value

β (95%CI)

p value

Average scores (0, 6 and 12 months)

 DAS28-ESR

None

Reference

 

Reference

 

Moderate

0.13 (−0.10, 0.36)

0.278

0.07 (−0.19, 0.33)

0.595

Severe

0.24 (0.02, 0.46)

0.030

0.03 (−0.29, 0.36)

0.838

 Pain

None

Reference

 

Reference

 

Moderate

5.72 (0.66, 10.77)

0.027

0.88 (−4.49, 6.25)

0.749

Severe

11.88 (7.06, 16.71)

<0.001

−0.88 (−7.57, 5.81)

0.796

 Fatigue

None

Reference

 

Reference

 

Moderate

13.12 (7.33, 18.91)

<0.001

10.13 (4.20, 16.07)

0.001

Severe

24.76 (19.56, 29.96)

<0.001

17.07 (9.76, 24.37)

<0.001

12-month outcomes

  

Crude

Odds ratio (95%CI)

p value

Adjusteda

Odds ratio (95%CI)

p value

 Remission DAS28-ESR (<2.6)

None

Reference

 

Reference

 

Moderate

1.28 (0.62, 2.65)

0.500

1.43 (0.64, 3.19)

0.377

Severe

0.78 (0.37, 1.62)

0.498

0.77 (0.35, 1.73)

0.535

 Change in pain (≥10 units)

None

Reference

 

Reference

 

Moderate

0.89 (0.46, 1.72)

0.726

0.66 (0.31, 1.37)

0.264

Severe

1.17 (0.64, 2.13)

0.608

1.19 (0.62, 2.29)

0.597

 Change in fatigue (≥10 units)

None

Reference

 

Reference

 

Moderate

1.61 (0.84, 3.11)

0.152

1.59 (0.76, 3.34)

0.219

Severe

1.25 (0.68, 2.28)

0.469

1.40 (0.72, 2.73)

0.321

  1. aAdjustment for age, gender, ethnicity, disease duration, NHS region and trial arm; Depression: none n=125; moderate n=76; severe n=94
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Arthritis Research & Therapy

ISSN: 1478-6362

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