|
Exposure
|
Hand OA progression events
|
Person-time [years]
|
IR per 1000 person-years
|
Crude HR (95% CI)
|
Adjusted HR (95% CI)a
|
Crude OR (95% CI)
|
Adjusted OR (95% CI)a
|
|---|
|
Analysis using baseline information only
|
|
csDMARD
|
526
|
3306.0
|
159.1
|
Ref (1.00)
|
Ref (1.00)
|
NA
|
NA
|
|
bDMARD
|
34
|
244.7
|
138.9
|
0.96 (0.71–1.31)
|
1.07 (0.78–1.46)
|
NA
|
NA
|
|
Combination
|
132
|
886.6
|
148.9
|
1.03 (0.85–1.24)
|
1.09 (0.89–1.32)
|
NA
|
NA
|
|
Past-use
|
8
|
53.8
|
148.7
|
1.24 (0.70–2.19)
|
1.15 (0.60–2.20)
|
NA
|
NA
|
|
Never-use
|
83
|
629.7
|
131.8
|
0.77 (0.61–0.97)
|
0.81 (0.63–1.02)
|
NA
|
NA
|
|
Time-varying analysis
|
|
csDMARD
|
421
|
2885.7
|
145.9
|
Ref (1.00)
|
Ref (1.00)
|
Ref (1.00)
|
Ref (1.00)
|
|
bDMARD
|
79
|
391.9
|
201.6
|
1.23 (0.98–1.54)
|
1.34 (1.07–1.69)
|
1.49 (1.15–1.93)
|
1.53 (1.17–2.00)
|
|
TNFi
|
67
|
357.6
|
187.4
|
1.16 (0.91–1.48)
|
1.26 (0.98–1.62)
|
1.36 (1.03–1.79)
|
1.41 (1.06–1.88)
|
|
Non-TNFi
|
12
|
34.3
|
349.9
|
1.85 (1.18–2.89)
|
2.07 (1.35–3.20)
|
2.94 (1.50–5.77)
|
2.79 (1.41–5.52)
|
|
Combination
|
236
|
1378.7
|
171.2
|
1.05 (0.90–1.22)
|
1.12 (0.96–1.31)
|
1.12 (0.95–1.33)
|
1.16 (0.97–1.38)
|
|
TNFi
|
210
|
1293.7
|
162.3
|
1.01 (0.86–1.18)
|
1.09 (0.92–1.28)
|
1.07 (0.90–1.28)
|
1.11 (0.93–1.33)
|
|
Non-TNFi
|
26
|
85
|
305.9
|
1.54 (1.10–2.15)
|
1.56 (1.10–2.23)
|
1.75 (1.13–2.73)
|
1.77 (1.13–2.77)
|
|
Past-use
|
24
|
128.4
|
186.9
|
0.96 (0.64–1.42)
|
0.96 (0.66–1.41)
|
1.36 (0.87–2.14)
|
1.30 (0.83–2.05)
|
|
Never-use
|
23
|
335.9
|
68.5
|
0.51 (0.31–0.83)
|
0.54 (0.33–0.90)
|
0.89 (0.57–1.38)
|
0.91 (0.58–1.42)
|
- bDMARD biologic disease-modifying antirheumatic drug, CI confidence interval, csDMARD conventional synthetic disease-modifying antirheumatic drug, IR incidence rate, HR hazard ratio, OA osteoarthritis, OR odds ratio, TNFi tumor necrosis factor inhibitor
- aAdjusted for age, sex (time-invariant), body mass index, rheumatoid arthritis duration, rheumatoid factor (time-invariant), DAS28-esr score, prednisone use, cardiac disorders, hypertension, osteoporosis, hand surgery, large joint osteoarthritis, or hip/knee arthroplasty
