Age ≤ 55 years at cohort entry
|
csDMARD
|
130
|
860.6
|
Ref (1.00)
|
Ref (1.00)
|
bDMARD
|
31
|
127.4
|
1.36 (0.93–2.00)
|
1.49 (1.01–2.21)
|
Combination
|
87
|
526.8
|
0.94 (0.73–1.22)
|
1.01 (0.78–1.33)
|
Past-use
|
10
|
39.2
|
0.96 (0.41–2.26)
|
1.09 (0.51–2.34)
|
Never-use
|
6
|
111.3
|
0.34 (0.14–0.80)
|
0.34 (0.14–0.84)
|
Age > 55 years at cohort entry
|
csDMARD
|
291
|
2025.1
|
Ref (1.00)
|
Ref (1.00)
|
bDMARD
|
48
|
264.6
|
1.13 (0.86–1.51)
|
1.21 (0.90–1.61)
|
Combination
|
149
|
851.9
|
1.11 (0.92–1.33)
|
1.16 (0.96–1.41)
|
Past-use
|
14
|
89.2
|
0.84 (0.52–1.36)
|
0.79 (0.48–1.29)
|
Never-use
|
17
|
224.6
|
0.62 (0.35–1.10)
|
0.68 (0.37–1.25)
|
Rheumatoid factor negative at cohort entry
|
csDMARD
|
132
|
1014.4
|
Ref (1.00)
|
Ref (1.00)
|
bDMARD
|
28
|
167.5
|
1.22 (0.83–1.80)
|
1.33 (0.90–1.96)
|
Combination
|
83
|
503.8
|
1.11 (0.85–1.44)
|
1.21 (0.92–1.58)
|
Past-use
|
7
|
35.3
|
1.21 (0.61–2.38)
|
1.16 (0.58–2.33)
|
Never-use
|
6
|
126.8
|
0.42 (0.19–0.92)
|
0.45 (0.20–1.03)
|
Rheumatoid factor positive at cohort entry
|
csDMARD
|
284
|
1832.4
|
Ref (1.00)
|
Ref (1.00)
|
bDMARD
|
45
|
210.7
|
1.20 (0.89–1.60)
|
1.40 (1.04–1.89)
|
Combination
|
139
|
809.4
|
0.99 (0.82–1.21)
|
1.09 (0.89–1.32)
|
Past-use
|
17
|
86.6
|
0.87 (0.52–1.42)
|
0.86 (0.55–1.36)
|
Never-use
|
16
|
186.2
|
0.58 (0.31–1.10)
|
0.59 (0.31–1.13)
|
Osteoporosis/fracture or osteoporosis treatment (additionally time-varying)
|
csDMARD without osteoporosis
|
334
|
2342.2
|
Ref (1.00)
|
Ref (1.00)
|
csDMARD with osteoporosis
|
87
|
543.5
|
0.88 (0.69–1.13)
|
0.87 (0.68–1.11)
|
bDMARD without osteoporosis
|
50
|
226.5
|
1.35 (1.04–1.77)
|
1.43 (1.09–1.88)
|
bDMARD with osteoporosis
|
29
|
165.4
|
1.00 (0.70–1.43)
|
1.04 (0.72–1.49)
|
Combination therapy without osteoporosis
|
165
|
952.5
|
1.06 (0.89–1.27)
|
1.13 (0.94–1.35)
|
Combination therapy with osteoporosis
|
71
|
426.2
|
0.94 (0.75–1.18)
|
0.95 (0.76–1.20)
|
Never/past-use without osteoporosis
|
38
|
390.3
|
0.65 (0.44–0.95)
|
0.69 (0.47–1.02)
|
Never/past-use with osteoporosis
|
9
|
74.0
|
0.68 (0.34–1.37)
|
0.66 (0.34–1.29)
|
Prednisone treatment (additionally time-varying)
|
csDMARD without prednisone
|
219
|
1509.1
|
0.79 (0.57–1.08)
|
0.72 (0.52–1.00)
|
csDMARD with prednisone
|
202
|
1376.6
|
0.87 (0.64–1.20)
|
0.81 (0.59–1.12)
|
bDMARD without prednisone
|
38
|
183.8
|
Ref (1.00)
|
Ref (1.00)
|
bDMARD with prednisone
|
41
|
208.2
|
1.03 (0.69–1.54)
|
1.07 (0.72–1.60)
|
Combination therapy without prednisone
|
128
|
679.8
|
0.90 (0.64–1.25)
|
0.88 (0.63–1.22)
|
Combination therapy with prednisone
|
108
|
699.0
|
0.83 (0.60–1.17)
|
0.83 (0.59–1.17)
|
Never/past-use without prednisone
|
22
|
287.8
|
0.39 (0.23–0.67)
|
0.36 (0.21–0.63)
|
Never/past-use with prednisone
|
25
|
176.5
|
0.90 (0.54–1.47)
|
0.87 (0.53–1.45)
|