Exposure | Incident hand OA events | Person-time [years] | IR per 1000 person-years | Crude HR (95% CI) | Adjusted HR (95% CI) a | Crude OR (95% CI) | Adjusted OR (95% CI)a |
---|---|---|---|---|---|---|---|
Analysis using baseline information only | |||||||
csDMARD | 119 | 2239.0 | 53.1 | Ref (1.00) | Ref (1.00) | NA | NA |
bDMARD | 10 | 147.2 | 67.9 | 1.44 (0.77–2.67) | 1.41 (0.75–2.65) | NA | NA |
Combination | 43 | 750.6 | 57.3 | 1.13 (0.80–1.60) | 1.09 (0.75–1.58) | NA | NA |
Past-use | 4 | 55.2 | 72.5 | 1.40 (0.54–3.61) | 1.85 (0.73–4.66) | NA | NA |
Never-use | 22 | 793.1 | 27.7 | 0.52 (0.33–0.84) | 0.59 (0.36–0.97) | NA | NA |
Time-varying analysis | |||||||
csDMARD | 96 | 1952.7 | 49.2 | Ref (1.00) | Ref (1.00) | Ref (1.00) | Ref (1.00) |
bDMARD | 20 | 377.6 | 53 | 0.94 (0.59–1.50) | 0.89 (0.56–1.43) | 1.14 (0.70–1.87) | 1.05 (0.63–1.75) |
Combination | 68 | 1212.7 | 56.1 | 1.06 (0.78–1.44) | 1.07 (0.78–1.46) | 1.08 (0.79–1.49) | 1.04 (0.75–1.44) |
Past-use | 7 | 111.4 | 62.8 | 1.06 (0.51–2.19) | 1.08 (0.50–2.33) | 1.51 (0.68–3.32) | 1.46 (0.66–3.25) |
Never-use | 7 | 330.7 | 21.2 | 0.55 (0.26–1.19) | 0.72 (0.32–1.61) | 0.92 (0.42–2.01) | 1.05 (0.47–2.33) |